1atn
From Proteopedia
(New page: 200px<br /> <applet load="1atn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1atn, resolution 2.8Å" /> '''ATOMIC STRUCTURE OF ...) |
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| - | [[Image:1atn.gif|left|200px]]<br /> | + | [[Image:1atn.gif|left|200px]]<br /><applet load="1atn" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1atn" size=" | + | |
caption="1atn, resolution 2.8Å" /> | caption="1atn, resolution 2.8Å" /> | ||
'''ATOMIC STRUCTURE OF THE ACTIN:DNASE I COMPLEX'''<br /> | '''ATOMIC STRUCTURE OF THE ACTIN:DNASE I COMPLEX'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The atomic models of the complex between rabbit skeletal muscle actin and | + | The atomic models of the complex between rabbit skeletal muscle actin and bovine pancreatic deoxyribonuclease I both in the ATP and ADP forms have been determined by X-ray analysis at an effective resolution of 2.8 A and 3A, respectively. The two structures are very similar. The actin molecule consists of two domains which can be further subdivided into two subdomains. ADP or ATP is located in the cleft between the domains with a calcium ion bound to the beta- or beta- and gamma-phosphates, respectively. The motif of a five-stranded beta sheet consisting of a beta meander and a right handed beta alpha beta unit appears in each domain suggesting that gene duplication might have occurred. These sheets have the same topology as that found in hexokinase. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1ATN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with CA, ACE, CH3 and ATP as [http://en.wikipedia.org/wiki/ligands ligands]. The following pages contain interesting information on the relation of 1ATN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb19_1.html Actin]]. Full crystallographic information is available from [http:// | + | 1ATN is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=ACE:'>ACE</scene>, <scene name='pdbligand=CH3:'>CH3</scene> and <scene name='pdbligand=ATP:'>ATP</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following pages contain interesting information on the relation of 1ATN with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb19_1.html Actin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ATN OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Holmes, K | + | [[Category: Holmes, K C.]] |
[[Category: Kabsch, W.]] | [[Category: Kabsch, W.]] | ||
| - | [[Category: Mannherz, H | + | [[Category: Mannherz, H G.]] |
[[Category: Pai, E.]] | [[Category: Pai, E.]] | ||
[[Category: Suck, D.]] | [[Category: Suck, D.]] | ||
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[[Category: endodeoxyribonuclease]] | [[Category: endodeoxyribonuclease]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:48:07 2008'' |
Revision as of 09:48, 21 February 2008
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ATOMIC STRUCTURE OF THE ACTIN:DNASE I COMPLEX
Contents |
Overview
The atomic models of the complex between rabbit skeletal muscle actin and bovine pancreatic deoxyribonuclease I both in the ATP and ADP forms have been determined by X-ray analysis at an effective resolution of 2.8 A and 3A, respectively. The two structures are very similar. The actin molecule consists of two domains which can be further subdivided into two subdomains. ADP or ATP is located in the cleft between the domains with a calcium ion bound to the beta- or beta- and gamma-phosphates, respectively. The motif of a five-stranded beta sheet consisting of a beta meander and a right handed beta alpha beta unit appears in each domain suggesting that gene duplication might have occurred. These sheets have the same topology as that found in hexokinase.
Disease
Known diseases associated with this structure: Myopathy, actin, congenital, with cores OMIM:[102610], Myopathy, actin, congenital, with excess of thin myofilaments OMIM:[102610], Myopathy, congenital, with fiber-type disporportion 1 OMIM:[102610], Myopathy, nemaline, 3 OMIM:[102610]
About this Structure
1ATN is a Protein complex structure of sequences from Bos taurus and Oryctolagus cuniculus with , , and as ligands. The following pages contain interesting information on the relation of 1ATN with [Actin]. Full crystallographic information is available from OCA.
Reference
Atomic structure of the actin:DNase I complex., Kabsch W, Mannherz HG, Suck D, Pai EF, Holmes KC, Nature. 1990 Sep 6;347(6288):37-44. PMID:2395459
Page seeded by OCA on Thu Feb 21 11:48:07 2008
Categories: Actin | Bos taurus | Myosin | Oryctolagus cuniculus | Protein complex | Holmes, K C. | Kabsch, W. | Mannherz, H G. | Pai, E. | Suck, D. | ACE | ATP | CA | CH3 | Endodeoxyribonuclease
