4dkr

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<StructureSection load='4dkr' size='340' side='right'caption='[[4dkr]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='4dkr' size='340' side='right'caption='[[4dkr]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dkr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Hiv-1 Hiv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DKR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dkr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_type_1_(BRU_ISOLATE) Human immunodeficiency virus type 1 (BRU ISOLATE)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DKR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LJ:N-[(1R,2R)-2-CARBAMIMIDAMIDO-2,3-DIHYDRO-1H-INDEN-1-YL]-N-(4-CHLORO-3-FLUOROPHENYL)ETHANEDIAMIDE'>0LJ</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0LJ:N-[(1R,2R)-2-CARBAMIMIDAMIDO-2,3-DIHYDRO-1H-INDEN-1-YL]-N-(4-CHLORO-3-FLUOROPHENYL)ETHANEDIAMIDE'>0LJ</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4dko|4dko]], [[4dkp|4dkp]], [[4dkq|4dkq]]</div></td></tr>
 
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HIV-1 Env ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11686 HIV-1])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkr OCA], [https://pdbe.org/4dkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dkr RCSB], [https://www.ebi.ac.uk/pdbsum/4dkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkr OCA], [https://pdbe.org/4dkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dkr RCSB], [https://www.ebi.ac.uk/pdbsum/4dkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkr ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q0ED31_9HIV1 Q0ED31_9HIV1] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hiv-1]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Courter, J R]]
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[[Category: Courter JR]]
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[[Category: Freire, E]]
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[[Category: Freire E]]
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[[Category: III, A B.Smith]]
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[[Category: Jones DM]]
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[[Category: Jones, D M]]
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[[Category: Kobayashi T]]
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[[Category: Kobayashi, T]]
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[[Category: Kwon YD]]
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[[Category: Kwon, Y D]]
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[[Category: Kwong PD]]
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[[Category: Kwong, P D]]
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[[Category: LaLonde JM]]
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[[Category: LaLonde, J M]]
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[[Category: Madani N]]
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[[Category: Madani, N]]
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[[Category: Mascola J]]
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[[Category: Mascola, J]]
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[[Category: Princiotto AM]]
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[[Category: Princiotto, A M]]
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[[Category: Schon A]]
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[[Category: Schon, A]]
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[[Category: Smith III AB]]
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[[Category: Sodroski, J]]
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[[Category: Sodroski J]]
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[[Category: Soeta, T]]
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[[Category: Soeta T]]
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[[Category: Sun, A W]]
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[[Category: Sun AW]]
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[[Category: Wu, X]]
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[[Category: Wu X]]
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[[Category: Aws-i-169]]
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[[Category: Cd4 mimic]]
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[[Category: Clade a/e]]
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[[Category: Hiv-1 gp120]]
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[[Category: Viral protein-inhibitor complex]]
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Revision as of 13:36, 22 February 2023

Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with AWS-I-169

PDB ID 4dkr

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