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4dkv

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<StructureSection load='4dkv' size='340' side='right'caption='[[4dkv]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
<StructureSection load='4dkv' size='340' side='right'caption='[[4dkv]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4dkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DKV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4dkv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DKV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DKV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KW:N-(4-CHLOROPHENYL)-N-{(S)-[5-(2-HYDROXYETHYL)-4-METHYL-1,3-THIAZOL-2-YL][(2S)-PIPERIDIN-2-YL]METHYL}ETHANEDIAMIDE'>0KW</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0KW:N-(4-CHLOROPHENYL)-N-{(S)-[5-(2-HYDROXYETHYL)-4-METHYL-1,3-THIAZOL-2-YL][(2S)-PIPERIDIN-2-YL]METHYL}ETHANEDIAMIDE'>0KW</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4dku|4dku]]</div></td></tr>
 
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">env ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkv OCA], [https://pdbe.org/4dkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dkv RCSB], [https://www.ebi.ac.uk/pdbsum/4dkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkv ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dkv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dkv OCA], [https://pdbe.org/4dkv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dkv RCSB], [https://www.ebi.ac.uk/pdbsum/4dkv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dkv ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/Q0ED31_9HIV1 Q0ED31_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).
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[https://www.uniprot.org/uniprot/A0A0M3KKW9_9HIV1 A0A0M3KKW9_9HIV1]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human immunodeficiency virus 1]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Debnath, A K]]
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[[Category: Debnath AK]]
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[[Category: Kwon, Y D]]
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[[Category: Kwon YD]]
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[[Category: Kwong, P D]]
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[[Category: Kwong PD]]
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[[Category: Cd4 mimic]]
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[[Category: Clade a/e]]
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[[Category: Hiv-1 gp120]]
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[[Category: Hydrolase]]
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[[Category: Nbd-10007]]
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Revision as of 13:36, 22 February 2023

Crystal structure of clade A/E 93TH057 HIV-1 gp120 core in complex with NBD-10007

PDB ID 4dkv

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