2lu3

<StructureSection load='2lu3' size='340' side='right'caption='[[2lu3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2lu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LU3 FirstGlance]. <br>

</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2lu4|2lu4]]</div></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu3 OCA], [https://pdbe.org/2lu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lu3 RCSB], [https://www.ebi.ac.uk/pdbsum/2lu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu3 ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/AAKB2_RAT AAKB2_RAT]] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity).

[[Category: Buffalo rat]]

[[Category: Gooley, P]]

[[Category: Koay, A]]

[[Category: Stapleton, D]]

[[Category: Carbohydrate binding module]]

[[Category: Sugar binding protein]]