2lxw

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==The solution structure of XIAP(RING)-binding domain of human XAF1==
==The solution structure of XIAP(RING)-binding domain of human XAF1==
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<StructureSection load='2lxw' size='340' side='right'caption='[[2lxw]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='2lxw' size='340' side='right'caption='[[2lxw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lxw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LXW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">XAF1, BIRC4BP, XIAPAF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxw OCA], [https://pdbe.org/2lxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxw RCSB], [https://www.ebi.ac.uk/pdbsum/2lxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lxw OCA], [https://pdbe.org/2lxw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lxw RCSB], [https://www.ebi.ac.uk/pdbsum/2lxw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lxw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/XAF1_HUMAN XAF1_HUMAN]] Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.<ref>PMID:11175744</ref> <ref>PMID:12029096</ref> <ref>PMID:16432762</ref> <ref>PMID:17613533</ref> <ref>PMID:17329253</ref>
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[https://www.uniprot.org/uniprot/XAF1_HUMAN XAF1_HUMAN] Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin; the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.<ref>PMID:11175744</ref> <ref>PMID:12029096</ref> <ref>PMID:16432762</ref> <ref>PMID:17613533</ref> <ref>PMID:17329253</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cho, C]]
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[[Category: Cho C]]
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[[Category: Guan, X]]
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[[Category: Guan X]]
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[[Category: Sze, K]]
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[[Category: Sze K]]
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[[Category: Tse, M]]
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[[Category: Tse M]]
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[[Category: Apoptosis]]
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[[Category: Xaf1]]
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Revision as of 13:18, 22 February 2023

The solution structure of XIAP(RING)-binding domain of human XAF1

PDB ID 2lxw

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