1av5
From Proteopedia
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| - | [[Image:1av5.gif|left|200px]]<br /> | + | [[Image:1av5.gif|left|200px]]<br /><applet load="1av5" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1av5" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="1av5, resolution 2.0Å" /> | caption="1av5, resolution 2.0Å" /> | ||
'''PKCI-SUBSTRATE ANALOG'''<br /> | '''PKCI-SUBSTRATE ANALOG'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AV5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with AP2 as [http://en.wikipedia.org/wiki/ligand ligand]. | + | 1AV5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with AP2 as [http://en.wikipedia.org/wiki/ligand ligand]. Known structural/functional Sites: <scene name='pdbsite=AVA:Active Site HIS Responsible For Forming The Transient Nu ...'>AVA</scene>, <scene name='pdbsite=AVB:Active Site HIS Responsible For Forming The Transient Nu ...'>AVB</scene>, <scene name='pdbsite=HNA:HIS Triad For Which This Family Was Named'>HNA</scene> and <scene name='pdbsite=HNB:HIS Triad For Which This Family Was Named'>HNB</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1AV5 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: protein kinase inhibitor]] | [[Category: protein kinase inhibitor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 14:21:51 2007'' |
Revision as of 12:12, 18 December 2007
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PKCI-SUBSTRATE ANALOG
Overview
The histidine triad (HIT) protein family is among the most ubiquitous and, highly conserved in nature, but a biological activity has not yet been, identified for any member of the HIT family. Fragile histidine triad, protein (FHIT) and protein kinase C interacting protein (PKCI) were used, in a structure-based approach to elucidate characteristics of in vivo, ligands and reactions. Crystallographic structures of apo, substrate, analog, pentacovalent transition-state analog, and product states of both, enzymes reveal a catalytic mechanism and define substrate characteristics, required for catalysis, thus unifying the HIT family as nucleotidyl, hydrolases, transferases, or both. The approach described here may be, useful in identifying structure-function relations between protein, families identified through genomics.
About this Structure
1AV5 is a Single protein structure of sequence from Homo sapiens with AP2 as ligand. Known structural/functional Sites: , , and . Full crystallographic information is available from OCA.
Reference
Structure-based analysis of catalysis and substrate definition in the HIT protein family., Lima CD, Klein MG, Hendrickson WA, Science. 1997 Oct 10;278(5336):286-90. PMID:9323207
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