6z2f
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Crystal structure of human AGX1 mutant complexed with UDPGLCNAC== |
| - | <StructureSection load='6z2f' size='340' side='right'caption='[[6z2f]]' scene=''> | + | <StructureSection load='6z2f' size='340' side='right'caption='[[6z2f]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6z2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z2F FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z2f OCA], [https://pdbe.org/6z2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z2f RCSB], [https://www.ebi.ac.uk/pdbsum/6z2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z2f ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UD1:URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE'>UD1</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z2f OCA], [https://pdbe.org/6z2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z2f RCSB], [https://www.ebi.ac.uk/pdbsum/6z2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z2f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/UAP1_HUMAN UAP1_HUMAN] Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Chen X]] |
| + | [[Category: Van Aalten DMF]] | ||
Current revision
Crystal structure of human AGX1 mutant complexed with UDPGLCNAC
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