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7c5o
From Proteopedia
(Difference between revisions)
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==Crystal Structure of H177A mutant of Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with NAD at 1.98 Angstrom resolution.== | ==Crystal Structure of H177A mutant of Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with NAD at 1.98 Angstrom resolution.== | ||
| - | <StructureSection load='7c5o' size='340' side='right'caption='[[7c5o]]' scene=''> | + | <StructureSection load='7c5o' size='340' side='right'caption='[[7c5o]], [[Resolution|resolution]] 1.98Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C5O FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7c5o]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecobd Ecobd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C5O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C5O FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c5o OCA], [https://pdbe.org/7c5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c5o RCSB], [https://www.ebi.ac.uk/pdbsum/7c5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c5o ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ECBD_2224 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=469008 ECOBD])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c5o OCA], [https://pdbe.org/7c5o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c5o RCSB], [https://www.ebi.ac.uk/pdbsum/7c5o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c5o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/A0A140NCK4_ECOBD A0A140NCK4_ECOBD]] Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG.[ARBA:ARBA00003501] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Ecobd]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bao | + | [[Category: Bao, L Y]] |
| - | [[Category: Bostrom | + | [[Category: Bostrom, I K]] |
| - | [[Category: Chen | + | [[Category: Chen, A Q]] |
| - | [[Category: Gu | + | [[Category: Gu, S H]] |
| - | [[Category: Ji | + | [[Category: Ji, C N]] |
| - | [[Category: Li | + | [[Category: Li, J X]] |
| - | [[Category: Liu | + | [[Category: Liu, M R]] |
| - | [[Category: Wang | + | [[Category: Wang, Y D]] |
| - | [[Category: Yao | + | [[Category: Yao, Y C]] |
| - | [[Category: Zhang L]] | + | [[Category: Zhang, L]] |
| + | [[Category: Ecgapdh 1]] | ||
| + | [[Category: Nad]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 15:57, 3 November 2021
Crystal Structure of H177A mutant of Glyceraldehyde-3-phosphate-dehydrogenase1 from Escherichia coli complexed with NAD at 1.98 Angstrom resolution.
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Categories: Ecobd | Large Structures | Bao, L Y | Bostrom, I K | Chen, A Q | Gu, S H | Ji, C N | Li, J X | Liu, M R | Wang, Y D | Yao, Y C | Zhang, L | Ecgapdh 1 | Nad | Oxidoreductase
