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1uyd

From Proteopedia

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Current revision (13:04, 13 December 2023) (edit) (undo)
 
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<StructureSection load='1uyd' size='340' side='right'caption='[[1uyd]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='1uyd' size='340' side='right'caption='[[1uyd]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1uyd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UYD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1uyd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UYD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UYD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PU8:9-BUTYL-8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE'>PU8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1byq|1byq]], [[1osf|1osf]], [[1yer|1yer]], [[1yes|1yes]], [[1yet|1yet]], [[1uy6|1uy6]], [[1uy7|1uy7]], [[1uy8|1uy8]], [[1uy9|1uy9]], [[1uyc|1uyc]], [[1uye|1uye]], [[1uyf|1uyf]], [[1uyg|1uyg]], [[1uyh|1uyh]], [[1uyi|1uyi]], [[1uyk|1uyk]], [[1uyl|1uyl]], [[1uym|1uym]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PU8:9-BUTYL-8-(2-CHLORO-3,4,5-TRIMETHOXY-BENZYL)-9H-PURIN-6-YLAMINE'>PU8</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyd OCA], [https://pdbe.org/1uyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uyd RCSB], [https://www.ebi.ac.uk/pdbsum/1uyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uyd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uyd OCA], [https://pdbe.org/1uyd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uyd RCSB], [https://www.ebi.ac.uk/pdbsum/1uyd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uyd ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aherne, W]]
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[[Category: Aherne W]]
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[[Category: Barril, X]]
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[[Category: Barril X]]
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[[Category: Beswick, M]]
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[[Category: Beswick M]]
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[[Category: Boxall, K]]
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[[Category: Boxall K]]
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[[Category: Collier, A]]
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[[Category: Collier A]]
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[[Category: Davies, N]]
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[[Category: Davies N]]
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[[Category: Drysdale, M]]
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[[Category: Drysdale M]]
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[[Category: Dymock, B]]
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[[Category: Dymock B]]
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[[Category: Fink, A]]
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[[Category: Fink A]]
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[[Category: Fromont, C]]
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[[Category: Fromont C]]
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[[Category: Hubbard, R E]]
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[[Category: Hubbard RE]]
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[[Category: Massey, A]]
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[[Category: Massey A]]
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[[Category: Sharp, S]]
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[[Category: Sharp S]]
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[[Category: Sheridan, L]]
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[[Category: Sheridan L]]
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[[Category: Surgenor, A]]
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[[Category: Surgenor A]]
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[[Category: Workman, P]]
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[[Category: Workman P]]
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[[Category: Wright, L]]
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[[Category: Wright L]]
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[[Category: Atp-binding]]
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[[Category: Atpase]]
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[[Category: Chaperone]]
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[[Category: Heat shock]]
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[[Category: Hsp90]]
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[[Category: Pu8]]
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Current revision

Human Hsp90-alpha with 9-Butyl-8-(2-chloro-3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine

PDB ID 1uyd

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