This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ej5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ej5.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1ej5.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ej5| PDB=1ej5 | SCENE= }}
{{STRUCTURE_1ej5| PDB=1ej5 | SCENE= }}
-
'''SOLUTION STRUCTURE OF THE AUTOINHIBITED CONFORMATION OF WASP'''
+
===SOLUTION STRUCTURE OF THE AUTOINHIBITED CONFORMATION OF WASP===
-
==Overview==
+
<!--
-
The Rho-family GTPase, Cdc42, can regulate the actin cytoskeleton through activation of Wiskott-Aldrich syndrome protein (WASP) family members. Activation relieves an autoinhibitory contact between the GTPase-binding domain and the carboxy-terminal region of WASP proteins. Here we report the autoinhibited structure of the GTPase-binding domain of WASP, which can be induced by the C-terminal region or by organic co-solvents. In the autoinhibited complex, intramolecular interactions with the GTPase-binding domain occlude residues of the C terminus that regulate the Arp2/3 actin-nucleating complex. Binding of Cdc42 to the GTPase-binding domain causes a dramatic conformational change, resulting in disruption of the hydrophobic core and release of the C terminus, enabling its interaction with the actin regulatory machinery. These data show that 'intrinsically unstructured' peptides such as the GTPase-binding domain of WASP can be induced into distinct structural and functional states depending on context.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10724160}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10724160 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10724160}}
==About this Structure==
==About this Structure==
-
1EJ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ5 OCA].
+
1EJ5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EJ5 OCA].
==Reference==
==Reference==
Line 29: Line 33:
[[Category: Alpha helix]]
[[Category: Alpha helix]]
[[Category: Beta-hairpin turn]]
[[Category: Beta-hairpin turn]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:09:50 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:49:33 2008''

Revision as of 21:49, 30 June 2008

Image:1ej5.png

Template:STRUCTURE 1ej5

SOLUTION STRUCTURE OF THE AUTOINHIBITED CONFORMATION OF WASP

Template:ABSTRACT PUBMED 10724160

About this Structure

1EJ5 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein., Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK, Nature. 2000 Mar 9;404(6774):151-8. PMID:10724160

Page seeded by OCA on Tue Jul 1 00:49:33 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ej5"
Personal tools