1bax

<StructureSection load='1bax' size='340' side='right'caption='[[1bax]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1bax]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mason-pfizer_monkey_virus Mason-pfizer monkey virus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1at7 1at7]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BAX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BAX FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bax FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bax OCA], [https://pdbe.org/1bax PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bax RCSB], [https://www.ebi.ac.uk/pdbsum/1bax PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bax ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/GAG_MPMV GAG_MPMV]] p10 is the matrix protein. P14 is the nucleocapsid protein. p27 is the capsid protein.

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== Publication Abstract from PubMed ==

The Mason-Pfizer monkey virus (M-PMV) is the prototype of the type D retroviruses. In type B and D retroviruses, the Gag protein pre-assembles before association with the membrane, whereas in type C retroviruses (lentiviruses, BLV/HTLV group) Gag is targeted efficiently to the plasma membrane, where the particle formation occurs. The N-terminal domain of Gag, the matrix protein (MA), plays a critical role in determining this morphogenic difference. We have determined the three-dimensional solution structure of the M-PMV MA by heteronuclear nuclear magnetic resonance. The protein contains four alpha-helices that are structurally similar to the known type C MA structures. This similarity implies possible common assembly units and membrane-binding mechanisms for type C and B/D retroviruses. In addition to this, the interpretation of mutagenesis data has enabled us to identify, for the first time, the structural basis of a putative intracellular targeting motif.

The three-dimensional solution structure of the matrix protein from the type D retrovirus, the Mason-Pfizer monkey virus, and implications for the morphology of retroviral assembly.,Conte MR, Klikova M, Hunter E, Ruml T, Matthews S EMBO J. 1997 Oct 1;16(19):5819-26. PMID:9312040<ref>PMID:9312040</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Mason-pfizer monkey virus]]

[[Category: Conte, M R]]

[[Category: Hunter, E]]

[[Category: Klikova, M]]

[[Category: Matthews, S]]

[[Category: Ruml, T]]

[[Category: Polyprotein]]