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2n23
From Proteopedia
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==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the N-terminal activation domain of EKLF (TAD1)== | ==NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the N-terminal activation domain of EKLF (TAD1)== | ||
| - | <StructureSection load='2n23' size='340' side='right'caption='[[2n23 | + | <StructureSection load='2n23' size='340' side='right'caption='[[2n23]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2n23]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2n23]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N23 FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n23 OCA], [https://pdbe.org/2n23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n23 RCSB], [https://www.ebi.ac.uk/pdbsum/2n23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n23 ProSAT]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n23 OCA], [https://pdbe.org/2n23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n23 RCSB], [https://www.ebi.ac.uk/pdbsum/2n23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n23 ProSAT]</span></td></tr> | + | |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[https://www.uniprot.org/uniprot/KLF1_HUMAN KLF1_HUMAN]] Hereditary persistence of fetal hemoglobin - beta-thalassemia;Hereditary persistence of fetal hemoglobin - sickle cell disease;Congenital dyserythropoietic anemia due to KLF1 mutation. Congenital dyserythropoietic anemia 4 (CDA4) [MIM:[https://omim.org/entry/613673 613673]]: A blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21055716</ref> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arseneault | + | [[Category: Saccharomyces cerevisiae S288C]] |
| - | [[Category: Lecoq | + | [[Category: Arseneault G]] |
| - | [[Category: Morse | + | [[Category: Lecoq L]] |
| - | [[Category: Omichinski | + | [[Category: Morse T]] |
| - | [[Category: Raiola | + | [[Category: Omichinski J]] |
| - | + | [[Category: Raiola L]] | |
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Revision as of 08:14, 8 March 2023
NMR structure of the complex between the PH domain of the Tfb1 subunit from TFIIH and the N-terminal activation domain of EKLF (TAD1)
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