5qda
From Proteopedia
(Difference between revisions)
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==Crystal structure of BACE complex with BMC013== | ==Crystal structure of BACE complex with BMC013== | ||
| - | <StructureSection load='5qda' size='340' side='right'caption='[[5qda]]' scene=''> | + | <StructureSection load='5qda' size='340' side='right'caption='[[5qda]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QDA FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5qda]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QDA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QDA FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qda OCA], [https://pdbe.org/5qda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qda RCSB], [https://www.ebi.ac.uk/pdbsum/5qda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qda ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E74:(4S)-4-[(1R)-1-hydroxy-2-({[3-(propan-2-yl)phenyl]methyl}amino)ethyl]-18-methoxy-3,15,17-triazatricyclo[14.3.1.1~6,10~]henicosa-1(20),6(21),7,9,16,18-hexaen-2-one'>E74</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qda FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qda OCA], [https://pdbe.org/5qda PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qda RCSB], [https://www.ebi.ac.uk/pdbsum/5qda PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qda ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Rondeau | + | [[Category: Burley SK]] |
| + | [[Category: Rondeau JM]] | ||
| + | [[Category: Shao C]] | ||
| + | [[Category: Yang H]] | ||
Revision as of 08:51, 7 February 2024
Crystal structure of BACE complex with BMC013
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