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6tbx

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Current revision (12:59, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6tbx' size='340' side='right'caption='[[6tbx]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
<StructureSection load='6tbx' size='340' side='right'caption='[[6tbx]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6tbx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TBX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6tbx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TBX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=N0Z:2,4-bis(azanyl)-9~{H}-pyrimido[4,5-b]indol-6-ol'>N0Z</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=N0Z:2,4-bis(azanyl)-9~{H}-pyrimido[4,5-b]indol-6-ol'>N0Z</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTR1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tbx OCA], [https://pdbe.org/6tbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tbx RCSB], [https://www.ebi.ac.uk/pdbsum/6tbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tbx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tbx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tbx OCA], [https://pdbe.org/6tbx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tbx RCSB], [https://www.ebi.ac.uk/pdbsum/6tbx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tbx ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trybb]]
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[[Category: Trypanosoma brucei brucei]]
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[[Category: Landi, G]]
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[[Category: Landi G]]
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[[Category: Mangani, S]]
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[[Category: Mangani S]]
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[[Category: Pozzi, C]]
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[[Category: Pozzi C]]
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[[Category: Tassone, G]]
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[[Category: Tassone G]]
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[[Category: Oxidoreductase]]
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[[Category: Pteridine reductase]]
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[[Category: Tbptr1]]
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[[Category: Tricyclic based inhibitor]]
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[[Category: Trypanosoma brucei]]
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Current revision

Trypanosoma brucei PTR1 (TbPTR1) in complex with a tricyclic-based inhibitor

PDB ID 6tbx

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