6tgh

==SHMT from Streptococcus thermophilus Tyr55Thr variant in complex with D-Serine both as external aldimine and as non-covalent complex==

<StructureSection load='6tgh' size='340' side='right'caption='[[6tgh]], [[Resolution|resolution]] 2.12&Aring;' scene=''>

<table><tr><td colspan='2'>[[6tgh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_thermophilus Streptococcus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TGH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TGH FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tgh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tgh OCA], [https://pdbe.org/6tgh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tgh RCSB], [https://www.ebi.ac.uk/pdbsum/6tgh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tgh ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/GLYA_STRT1 GLYA_STRT1] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]

[[Category: Streptococcus thermophilus]]

[[Category: Bujons J]]

[[Category: Clapes P]]

[[Category: Uson I]]