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2nov

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Current revision (10:17, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2nov' size='340' side='right'caption='[[2nov]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
<StructureSection load='2nov' size='340' side='right'caption='[[2nov]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2nov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"diplococcus_pneumoniae"_(klein_1884)_weichselbaum_1886 "diplococcus pneumoniae" (klein 1884) weichselbaum 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NOV FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2nov]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NOV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NOV FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">parC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 "Diplococcus pneumoniae" (Klein 1884) Weichselbaum 1886])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nov OCA], [https://pdbe.org/2nov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nov RCSB], [https://www.ebi.ac.uk/pdbsum/2nov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nov ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nov FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nov OCA], [https://pdbe.org/2nov PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nov RCSB], [https://www.ebi.ac.uk/pdbsum/2nov PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nov ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>
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[https://www.uniprot.org/uniprot/Q3HYJ3_STREE Q3HYJ3_STREE]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Achari, A]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Ferrara, J D]]
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[[Category: Achari A]]
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[[Category: Fisher, L M]]
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[[Category: Ferrara JD]]
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[[Category: Laponogov, I]]
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[[Category: Fisher LM]]
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[[Category: Pan, X S]]
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[[Category: Laponogov I]]
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[[Category: Sanderson, M R]]
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[[Category: Pan XS]]
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[[Category: Sohi, M K]]
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[[Category: Sanderson MR]]
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[[Category: Veselkov, D A]]
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[[Category: Sohi MK]]
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[[Category: Yang, C]]
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[[Category: Veselkov DA]]
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[[Category: Dna binding]]
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[[Category: Yang C]]
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[[Category: Dna cleavage]]
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[[Category: Gram-positive bacteria]]
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[[Category: Isomerase]]
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[[Category: Parc]]
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[[Category: Protein]]
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[[Category: Quinolone target]]
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[[Category: Topo iv]]
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Current revision

Breakage-reunion domain of S.pneumoniae topo IV: crystal structure of a gram-positive quinolone target

PDB ID 2nov

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