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2nuu

From Proteopedia

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Current revision (08:55, 25 October 2023) (edit) (undo)
 
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<StructureSection load='2nuu' size='340' side='right'caption='[[2nuu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2nuu' size='340' side='right'caption='[[2nuu]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2nuu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NUU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2nuu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NUU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NUU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">amtB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895]), glnK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nuu OCA], [https://pdbe.org/2nuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nuu RCSB], [https://www.ebi.ac.uk/pdbsum/2nuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nuu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nuu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nuu OCA], [https://pdbe.org/2nuu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nuu RCSB], [https://www.ebi.ac.uk/pdbsum/2nuu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nuu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/AMTB_ECOLI AMTB_ECOLI]] Involved in the uptake of ammonia. [[https://www.uniprot.org/uniprot/GLNK_ECOLI GLNK_ECOLI]] P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).
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[https://www.uniprot.org/uniprot/AMTB_ECOLI AMTB_ECOLI] Involved in the uptake of ammonia.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bullough, P A]]
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[[Category: Bullough PA]]
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[[Category: Conroy, M J]]
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[[Category: Conroy MJ]]
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[[Category: Durand, A]]
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[[Category: Durand A]]
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[[Category: Li, X D]]
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[[Category: Li X-D]]
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[[Category: Lupo, D]]
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[[Category: Lupo D]]
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[[Category: Merrick, M]]
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[[Category: Merrick M]]
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[[Category: Winkler, F K]]
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[[Category: Winkler FK]]
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[[Category: Ammonia transport]]
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[[Category: Membrane protein complex]]
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[[Category: Nitrogen regulation]]
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[[Category: Transport protein-signaling protein complex]]
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Current revision

Regulating the Escherichia coli ammonia channel: the crystal structure of the AmtB-GlnK complex

PDB ID 2nuu

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