2nwm

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Current revision (00:11, 28 December 2023) (edit) (undo)
 
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==Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin==
==Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin==
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<StructureSection load='2nwm' size='340' side='right'caption='[[2nwm]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2nwm' size='340' side='right'caption='[[2nwm]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2nwm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NWM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2nwm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2NWM FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Vinexin ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nwm OCA], [https://pdbe.org/2nwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nwm RCSB], [https://www.ebi.ac.uk/pdbsum/2nwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nwm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2nwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2nwm OCA], [https://pdbe.org/2nwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2nwm RCSB], [https://www.ebi.ac.uk/pdbsum/2nwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2nwm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/VINEX_HUMAN VINEX_HUMAN]] Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
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[https://www.uniprot.org/uniprot/VINEX_HUMAN VINEX_HUMAN] Vinexin alpha isoform promotes up-regulation of actin stress fiber formation. Vinexin beta isoform plays a role in cell spreading and enhances the activation of JNK/SAPK in response to EGF stimulation by using its third SH3 domain.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Shi, Y]]
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[[Category: Shi Y]]
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[[Category: Wu, J]]
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[[Category: Wu J]]
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[[Category: Yao, B]]
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[[Category: Yao B]]
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[[Category: Zhang, J]]
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[[Category: Zhang J]]
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[[Category: Cell adhesion]]
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[[Category: Vinexin sh3 domain]]
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Current revision

Solution structure of the first SH3 domain of human Vinexin and its interaction with the peptides from Vinculin

PDB ID 2nwm

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