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2o0l

From Proteopedia

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Current revision (00:12, 28 December 2023) (edit) (undo)
 
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<StructureSection load='2o0l' size='340' side='right'caption='[[2o0l]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='2o0l' size='340' side='right'caption='[[2o0l]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2o0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O0L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2o0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O0L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S4M:5-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5-DEOXYADENOSINE'>S4M</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2o05|2o05]], [[2o06|2o06]], [[2o07|2o07]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=S4M:5-[(S)-(3-AMINOPROPYL)(METHYL)-LAMBDA~4~-SULFANYL]-5-DEOXYADENOSINE'>S4M</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SRM, SPS1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Spermidine_synthase Spermidine synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.16 2.5.1.16] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o0l OCA], [https://pdbe.org/2o0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o0l RCSB], [https://www.ebi.ac.uk/pdbsum/2o0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o0l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o0l OCA], [https://pdbe.org/2o0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o0l RCSB], [https://www.ebi.ac.uk/pdbsum/2o0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o0l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SPEE_HUMAN SPEE_HUMAN]] Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.
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[https://www.uniprot.org/uniprot/SPEE_HUMAN SPEE_HUMAN] Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3-diaminopropane. Has extremely low activity towards spermidine.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Spermidine synthase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bochkarev A]]
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[[Category: Bochkarev, A]]
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[[Category: Edwards AM]]
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[[Category: Edwards, A M]]
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[[Category: Loppnau P]]
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[[Category: Loppnau, P]]
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[[Category: Min J]]
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[[Category: Min, J]]
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[[Category: Plotnikov AN]]
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[[Category: Plotnikov, A N]]
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[[Category: Sundstrom M]]
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[[Category: Structural genomic]]
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[[Category: Weigelt J]]
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[[Category: Sundstrom, M]]
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[[Category: Wu H]]
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[[Category: Weigelt, J]]
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[[Category: Zeng H]]
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[[Category: Wu, H]]
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[[Category: Zeng, H]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Human spermidine synthase

PDB ID 2o0l

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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