This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2o22
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand== | ==Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand== | ||
| - | <StructureSection load='2o22' size='340' side='right'caption='[[2o22 | + | <StructureSection load='2o22' size='340' side='right'caption='[[2o22]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2o22]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2o22]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O22 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O22 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LIU:N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]-4-(4,4-DIMETHYLPIPERIDIN-1-YL)BENZAMIDE'>LIU</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LIU:N-[(4-{[1,1-DIMETHYL-2-(PHENYLTHIO)ETHYL]AMINO}-3-NITROPHENYL)SULFONYL]-4-(4,4-DIMETHYLPIPERIDIN-1-YL)BENZAMIDE'>LIU</scene></td></tr> | |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o22 OCA], [https://pdbe.org/2o22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o22 RCSB], [https://www.ebi.ac.uk/pdbsum/2o22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o22 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o22 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o22 OCA], [https://pdbe.org/2o22 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o22 RCSB], [https://www.ebi.ac.uk/pdbsum/2o22 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o22 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 39: | Line 38: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Belli | + | [[Category: Belli BA]] |
| - | [[Category: Bruncko | + | [[Category: Bruncko M]] |
| - | [[Category: Ding | + | [[Category: Ding H]] |
| - | [[Category: Elmore | + | [[Category: Elmore SW]] |
| - | [[Category: Fesik | + | [[Category: Fesik SW]] |
| - | [[Category: Joseph | + | [[Category: Joseph MK]] |
| - | [[Category: Kunzer | + | [[Category: Kunzer A]] |
| - | [[Category: Martineau | + | [[Category: Martineau D]] |
| - | [[Category: McClellan | + | [[Category: McClellan WJ]] |
| - | [[Category: Mitten | + | [[Category: Mitten M]] |
| - | [[Category: Ng | + | [[Category: Ng SC]] |
| - | [[Category: Nimmer | + | [[Category: Nimmer PM]] |
| - | [[Category: Oltersdorf | + | [[Category: Oltersdorf T]] |
| - | [[Category: Oost | + | [[Category: Oost TK]] |
| - | [[Category: Park | + | [[Category: Park CM]] |
| - | [[Category: Petros | + | [[Category: Petros AM]] |
| - | [[Category: Rosenberg | + | [[Category: Rosenberg SH]] |
| - | [[Category: Shoemaker | + | [[Category: Shoemaker AR]] |
| - | [[Category: Song | + | [[Category: Song X]] |
| - | [[Category: Wang | + | [[Category: Wang X]] |
| - | [[Category: Wendt | + | [[Category: Wendt MD]] |
| - | [[Category: Zhang | + | [[Category: Zhang H]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand
| |||||||||||
Categories: Homo sapiens | Large Structures | Belli BA | Bruncko M | Ding H | Elmore SW | Fesik SW | Joseph MK | Kunzer A | Martineau D | McClellan WJ | Mitten M | Ng SC | Nimmer PM | Oltersdorf T | Oost TK | Park CM | Petros AM | Rosenberg SH | Shoemaker AR | Song X | Wang X | Wendt MD | Zhang H
