This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1ekg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ekg.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1ekg.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ekg| PDB=1ekg | SCENE= }}
{{STRUCTURE_1ekg| PDB=1ekg | SCENE= }}
-
'''MATURE HUMAN FRATAXIN'''
+
===MATURE HUMAN FRATAXIN===
-
==Overview==
+
<!--
-
Friedreich's ataxia, an autosomal recessive neurodegenerative disorder characterized by progressive gait and limb ataxia, cardiomyopathy, and diabetes mellitus, is caused by decreased frataxin production or function. The structure of human frataxin, which we have determined at 1.8-A resolution, reveals a novel protein fold. A five-stranded, antiparallel beta sheet provides a flat platform, which supports a pair of parallel alpha helices, to form a compact alphabeta sandwich. A cluster of 12 acidic residues from the first helix and the first strand of the large sheet form a contiguous anionic surface on the protein. The overall protein structure and the anionic patch are conserved in eukaryotes, including animals, plants, and yeast, and in prokaryotes. Additional conserved residues create an extended 1008-A(2) patch on a distinct surface of the protein. Side chains of disease-associated mutations either contribute to the anionic patch, help create the second conserved surface, or point toward frataxin's hydrophobic core. These structural findings predict potential modes of protein-protein and protein-iron binding.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10900192}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10900192 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10900192}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Iron transport]]
[[Category: Iron transport]]
[[Category: Mitochondrial]]
[[Category: Mitochondrial]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:12:44 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:53:32 2008''

Revision as of 21:53, 30 June 2008

Image:1ekg.png

Template:STRUCTURE 1ekg

MATURE HUMAN FRATAXIN

Template:ABSTRACT PUBMED 10900192

About this Structure

1EKG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human frataxin., Dhe-Paganon S, Shigeta R, Chi YI, Ristow M, Shoelson SE, J Biol Chem. 2000 Oct 6;275(40):30753-6. PMID:10900192

Page seeded by OCA on Tue Jul 1 00:53:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ekg"
Personal tools