6xaz
From Proteopedia
(Difference between revisions)
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==Structure of the PR domain from human PRDM5== | ==Structure of the PR domain from human PRDM5== | ||
| - | <StructureSection load='6xaz' size='340' side='right'caption='[[6xaz]]' scene=''> | + | <StructureSection load='6xaz' size='340' side='right'caption='[[6xaz]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAZ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xaz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAZ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xaz OCA], [https://pdbe.org/6xaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xaz RCSB], [https://www.ebi.ac.uk/pdbsum/6xaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xaz ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRDM5, PFM2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xaz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xaz OCA], [https://pdbe.org/6xaz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xaz RCSB], [https://www.ebi.ac.uk/pdbsum/6xaz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xaz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/PRDM5_HUMAN PRDM5_HUMAN]] Brittle cornea syndrome. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PRDM5_HUMAN PRDM5_HUMAN]] Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes. May regulate the expression of proteins involved in extracellular matrix development and maintenance, including fibrillar collagens, such as COL4A1 and COL11A1, connective tissue components, such as HAPLN1, and molecules regulating cell migration and adhesion, including EDIL3 and TGFB2. May cause G2/M arrest and apoptosis in cancer cells.<ref>PMID:15077163</ref> <ref>PMID:17636019</ref> <ref>PMID:21664999</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Briknarova K]] | + | [[Category: Briknarova, K]] |
| - | [[Category: Kerchner | + | [[Category: Kerchner, K M]] |
| - | [[Category: Mou | + | [[Category: Mou, T C]] |
| - | [[Category: Sprang | + | [[Category: Sprang, S R]] |
| + | [[Category: Prdm5]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 07:42, 25 June 2021
Structure of the PR domain from human PRDM5
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