6z6z
From Proteopedia
(Difference between revisions)
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==Crystal structure of an Anticalin directed towards colchicine without ligand== | ==Crystal structure of an Anticalin directed towards colchicine without ligand== | ||
| - | <StructureSection load='6z6z' size='340' side='right'caption='[[6z6z]]' scene=''> | + | <StructureSection load='6z6z' size='340' side='right'caption='[[6z6z]], [[Resolution|resolution]] 1.78Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z6Z FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6z6z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z6Z FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z6z OCA], [https://pdbe.org/6z6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z6z RCSB], [https://www.ebi.ac.uk/pdbsum/6z6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z6z ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z6z OCA], [https://pdbe.org/6z6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z6z RCSB], [https://www.ebi.ac.uk/pdbsum/6z6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z6z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NGAL_HUMAN NGAL_HUMAN] Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.<ref>PMID:12453413</ref> | ||
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| + | ==See Also== | ||
| + | *[[Neutrophil gelatinase-associated lipocalin|Neutrophil gelatinase-associated lipocalin]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Eichinger A]] | [[Category: Eichinger A]] | ||
[[Category: Skerra A]] | [[Category: Skerra A]] | ||
Revision as of 13:42, 24 January 2024
Crystal structure of an Anticalin directed towards colchicine without ligand
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