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2obx

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Current revision (10:34, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2obx' size='340' side='right'caption='[[2obx]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
<StructureSection load='2obx' size='340' side='right'caption='[[2obx]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2obx]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_33669 Atcc 33669]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OBX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2obx]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesorhizobium_loti Mesorhizobium loti]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OBX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=INI:5-NITRO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE'>INI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.53&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1t13|1t13]], [[1di0|1di0]], [[1xn1|1xn1]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=INI:5-NITRO-6-RIBITYL-AMINO-2,4(1H,3H)-PYRIMIDINEDIONE'>INI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ribH1, ribH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=381 ATCC 33669])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/6,7-dimethyl-8-ribityllumazine_synthase 6,7-dimethyl-8-ribityllumazine synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.78 2.5.1.78] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2obx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2obx OCA], [https://pdbe.org/2obx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2obx RCSB], [https://www.ebi.ac.uk/pdbsum/2obx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2obx ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2obx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2obx OCA], [https://pdbe.org/2obx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2obx RCSB], [https://www.ebi.ac.uk/pdbsum/2obx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2obx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RISB1_RHILO RISB1_RHILO]] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:17854827</ref>
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[https://www.uniprot.org/uniprot/RISB2_RHILO RISB2_RHILO] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:17854827</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 6,7-dimethyl-8-ribityllumazine synthase]]
 
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[[Category: Atcc 33669]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bacher, A]]
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[[Category: Mesorhizobium loti]]
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[[Category: Bonomi, H R]]
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[[Category: Bacher A]]
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[[Category: Braden, B C]]
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[[Category: Bonomi HR]]
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[[Category: Fischer, M]]
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[[Category: Braden BC]]
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[[Category: Goldbaum, F A]]
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[[Category: Fischer M]]
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[[Category: Guimaraes, B G]]
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[[Category: Goldbaum FA]]
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[[Category: Haase, I]]
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[[Category: Guimaraes BG]]
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[[Category: Klinke, S]]
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[[Category: Haase I]]
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[[Category: Zylberman, V]]
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[[Category: Klinke S]]
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[[Category: Alpha-beta]]
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[[Category: Zylberman V]]
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[[Category: Lumazine synthase]]
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[[Category: Transferase]]
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Current revision

Lumazine synthase RibH2 from Mesorhizobium loti (Gene mll7281, Swiss-Prot entry Q986N2) complexed with inhibitor 5-Nitro-6-(D-Ribitylamino)-2,4(1H,3H) Pyrimidinedione

PDB ID 2obx

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OCA

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