2ocs

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Current revision (00:16, 28 December 2023) (edit) (undo)
 
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<StructureSection load='2ocs' size='340' side='right'caption='[[2ocs]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
<StructureSection load='2ocs' size='340' side='right'caption='[[2ocs]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ocs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OCS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ocs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OCS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OCS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SLC9A3R2, NHERF2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ocs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ocs OCA], [https://pdbe.org/2ocs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ocs RCSB], [https://www.ebi.ac.uk/pdbsum/2ocs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ocs ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ocs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ocs OCA], [https://pdbe.org/2ocs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ocs RCSB], [https://www.ebi.ac.uk/pdbsum/2ocs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ocs ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NHRF2_HUMAN NHRF2_HUMAN]] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.<ref>PMID:9096337</ref> <ref>PMID:10455146</ref>
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[https://www.uniprot.org/uniprot/NHRF2_HUMAN NHRF2_HUMAN] Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May also act as scaffold protein in the nucleus.<ref>PMID:9096337</ref> <ref>PMID:10455146</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Sodium-hydrogen exchange regulatory factor|Sodium-hydrogen exchange regulatory factor]]
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*[[Sodium-hydrogen exchange regulatory factor 3D structures|Sodium-hydrogen exchange regulatory factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge, G]]
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[[Category: Berridge G]]
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[[Category: Burgess, N]]
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[[Category: Burgess N]]
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[[Category: Doyle, D A]]
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[[Category: Doyle DA]]
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[[Category: Edwards, A]]
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[[Category: Edwards A]]
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[[Category: Elkins, J]]
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[[Category: Elkins J]]
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[[Category: Gileadi, C]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, O]]
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[[Category: Gileadi O]]
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[[Category: Gorrec, F]]
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[[Category: Gorrec F]]
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[[Category: Papagrigoriou, E]]
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[[Category: Papagrigoriou E]]
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[[Category: Phillips, C]]
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[[Category: Phillips C]]
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[[Category: Structural genomic]]
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[[Category: Salah E]]
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[[Category: Salah, E]]
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[[Category: Savitsky P]]
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[[Category: Savitsky, P]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Ugochukwu E]]
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[[Category: Ugochukwu, E]]
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[[Category: Umeano C]]
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[[Category: Umeano, C]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Sgc]]
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[[Category: Structural protein]]
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Current revision

The crystal structure of the first PDZ domain of human NHERF-2 (SLC9A3R2)

PDB ID 2ocs

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ocs"
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