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2odd

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Current revision (00:17, 28 December 2023) (edit) (undo)
 
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==Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor==
==Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor==
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<StructureSection load='2odd' size='340' side='right'caption='[[2odd]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
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<StructureSection load='2odd' size='340' side='right'caption='[[2odd]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2odd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ODD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2odd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ODD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ODD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2od1|2od1]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SMRT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), AML1-ETO ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odd OCA], [https://pdbe.org/2odd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2odd RCSB], [https://www.ebi.ac.uk/pdbsum/2odd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2odd ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2odd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2odd OCA], [https://pdbe.org/2odd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2odd RCSB], [https://www.ebi.ac.uk/pdbsum/2odd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2odd ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
 
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[[https://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Note=A chromosomal aberration involving RUNX1T1 is a cause of acute myeloid leukemia (AML-M2). Translocation t(8;21)(q22;q22) with RUNX1/AML1.<ref>PMID:8334990</ref> <ref>PMID:7541640</ref> <ref>PMID:8353289</ref> <ref>PMID:1423235</ref> Defects in RUNX1T1 may be a cause of colorectal cancer (CRC) [MIM:[https://omim.org/entry/114500 114500]].
 
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MTG8_HUMAN MTG8_HUMAN]] Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12.<ref>PMID:10973986</ref> <ref>PMID:16803958</ref>
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[https://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bushweller, J H]]
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[[Category: Bushweller JH]]
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[[Category: Chen, W]]
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[[Category: Chen W]]
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[[Category: Cheney, M D]]
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[[Category: Cheney MD]]
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[[Category: Cierpicki, T]]
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[[Category: Cierpicki T]]
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[[Category: Gaudet, J]]
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[[Category: Gaudet J]]
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[[Category: Hartman, K]]
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[[Category: Hartman K]]
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[[Category: Klet, R C]]
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[[Category: Klet RC]]
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[[Category: Laue, T M]]
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[[Category: Laue TM]]
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[[Category: Liu, Y Z]]
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[[Category: Liu YZ]]
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[[Category: Roudaia, L]]
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[[Category: Roudaia L]]
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[[Category: Speck, N A]]
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[[Category: Speck NA]]
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[[Category: Cross-braced topology]]
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[[Category: Metal binding protein]]
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[[Category: Mynd zinc finger]]
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[[Category: Poly-proline]]
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[[Category: Proline-tryptophan interaction]]
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Current revision

Solution structure of the MYND domain from AML1-ETO complexed with SMRT, a corepressor

PDB ID 2odd

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