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1elv

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{{STRUCTURE_1elv| PDB=1elv | SCENE= }}
{{STRUCTURE_1elv| PDB=1elv | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COMPLEMENT C1S PROTEASE'''
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===CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COMPLEMENT C1S PROTEASE===
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==Overview==
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C1s is the highly specific modular serine protease that mediates the proteolytic activity of the C1 complex and thereby triggers activation of the complement cascade. The crystal structure of a catalytic fragment from human C1s comprising the second complement control protein (CCP2) module and the chymotrypsin-like serine protease (SP) domain has been determined and refined to 1.7 A resolution. In the areas surrounding the active site, the SP structure reveals a restricted access to subsidiary substrate binding sites that could be responsible for the narrow specificity of C1s. The ellipsoidal CCP2 module is oriented perpendicularly to the surface of the SP domain. This arrangement is maintained through a rigid module-domain interface involving intertwined proline- and tyrosine-rich polypeptide segments. The relative orientation of SP and CCP2 is consistent with the fact that the latter provides additional substrate recognition sites for the C4 substrate. This structure provides a first example of a CCP-SP assembly that is conserved in diverse extracellular proteins. Its implications in the activation mechanism of C1 are discussed.
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(as it appears on PubMed at http://www.pubmed.gov), where 10775260 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10775260}}
==About this Structure==
==About this Structure==
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[[Category: Rossi, V.]]
[[Category: Rossi, V.]]
[[Category: Trypsin-like serin protease]]
[[Category: Trypsin-like serin protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:15:33 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:57:30 2008''

Revision as of 21:57, 30 June 2008

Image:1elv.png

Template:STRUCTURE 1elv

CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN COMPLEMENT C1S PROTEASE

Template:ABSTRACT PUBMED 10775260

About this Structure

1ELV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human complement c1s: a serine protease with a handle., Gaboriaud C, Rossi V, Bally I, Arlaud GJ, Fontecilla-Camps JC, EMBO J. 2000 Apr 17;19(8):1755-65. PMID:10775260

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