This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2opv
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution NMR Structure of the Second Domain of KSRP== | ==Solution NMR Structure of the Second Domain of KSRP== | ||
| - | <StructureSection load='2opv' size='340' side='right'caption='[[2opv | + | <StructureSection load='2opv' size='340' side='right'caption='[[2opv]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2opv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2opv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OPV FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opv OCA], [https://pdbe.org/2opv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opv RCSB], [https://www.ebi.ac.uk/pdbsum/2opv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opv ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2opv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2opv OCA], [https://pdbe.org/2opv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2opv RCSB], [https://www.ebi.ac.uk/pdbsum/2opv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2opv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/FUBP2_HUMAN FUBP2_HUMAN] Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.<ref>PMID:9136930</ref> <ref>PMID:8940189</ref> <ref>PMID:11003644</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 24: | Line 23: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Diaz-Moreno | + | [[Category: Diaz-Moreno I]] |
| - | [[Category: Garcia-Mayoral | + | [[Category: Garcia-Mayoral MF]] |
| - | [[Category: Hollingworth | + | [[Category: Hollingworth D]] |
| - | [[Category: Ramos | + | [[Category: Ramos A]] |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution NMR Structure of the Second Domain of KSRP
| |||||||||||
