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1em6

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{{STRUCTURE_1em6| PDB=1em6 | SCENE= }}
{{STRUCTURE_1em6| PDB=1em6 | SCENE= }}
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'''HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH GLCNAC AND CP-526,423'''
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===HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH GLCNAC AND CP-526,423===
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==Overview==
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Background: Glycogen phosphorylases catalyze the breakdown of glycogen to glucose-1-phosphate for glycolysis. Maintaining control of blood glucose levels is critical in minimizing the debilitating effects of diabetes, making liver glycogen phosphorylase a potential therapeutic target.Results: The binding site in human liver glycogen phosphorylase (HLGP) for a class of promising antidiabetic agents was identified crystallographically. The site is novel and functions allosterically by stabilizing the inactive conformation of HLGP. The initial view of the complex revealed key structural information and inspired the design of a new class of inhibitors which bind with nanomolar affinity and whose crystal structure is also described. Conclusions: We have identified the binding site of a new class of allosteric HLGP inhibitors. The crystal structure revealed the details of inhibitor binding, led to the design of a new class of compounds, and should accelerate efforts to develop therapeutically relevant molecules for the treatment of diabetes.
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(as it appears on PubMed at http://www.pubmed.gov), where 10980448 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10980448}}
==About this Structure==
==About this Structure==
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[[Category: Allosteric binding]]
[[Category: Allosteric binding]]
[[Category: Allosteric site]]
[[Category: Allosteric site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:16:01 2008''
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Revision as of 21:58, 30 June 2008

Image:1em6.png

Template:STRUCTURE 1em6

HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH GLCNAC AND CP-526,423

Template:ABSTRACT PUBMED 10980448

About this Structure

1EM6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Human liver glycogen phosphorylase inhibitors bind at a new allosteric site., Rath VL, Ammirati M, Danley DE, Ekstrom JL, Gibbs EM, Hynes TR, Mathiowetz AM, McPherson RK, Olson TV, Treadway JL, Hoover DJ, Chem Biol. 2000 Sep;7(9):677-82. PMID:10980448

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