This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7b6h

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:47, 1 May 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='7b6h' size='340' side='right'caption='[[7b6h]], [[Resolution|resolution]] 5.40&Aring;' scene=''>
<StructureSection load='7b6h' size='340' side='right'caption='[[7b6h]], [[Resolution|resolution]] 5.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[7b6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B6H FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[7b6h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7B6H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7B6H FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gry, Dmel\CG17569, gryz, l(3)63Bd, TRAPPC11, CG17569, Dmel_CG17569 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6h OCA], [https://pdbe.org/7b6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b6h RCSB], [https://www.ebi.ac.uk/pdbsum/7b6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7b6h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7b6h OCA], [https://pdbe.org/7b6h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7b6h RCSB], [https://www.ebi.ac.uk/pdbsum/7b6h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7b6h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/Q8IRE3_DROME Q8IRE3_DROME]] Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.[ARBA:ARBA00001995]
+
[https://www.uniprot.org/uniprot/Q8IRE3_DROME Q8IRE3_DROME] Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.[ARBA:ARBA00001995]
-
<div style="background-color:#fffaf0;">
+
-
== Publication Abstract from PubMed ==
+
-
The TRAPP complexes are nucleotide exchange factors that play essential roles in membrane traffic and autophagy. TRAPPII activates Rab11, and TRAPPIII activates Rab1, with the two complexes sharing a core of small subunits that affect nucleotide exchange but being distinguished by specific large subunits that are essential for activity in vivo. Crystal structures of core subunits have revealed the mechanism of Rab activation, but how the core and the large subunits assemble to form the complexes is unknown. We report a cryo-EM structure of the entire Drosophila TRAPPIII complex. The TRAPPIII-specific subunits TRAPPC8 and TRAPPC11 hold the catalytic core like a pair of tongs, with TRAPPC12 and TRAPPC13 positioned at the joint between them. TRAPPC2 and TRAPPC2L link the core to the two large arms, with the interfaces containing residues affected by disease-causing mutations. The TRAPPC8 arm is positioned such that it would contact Rab1 that is bound to the core, indicating how the arm could determine the specificity of the complex. A lower resolution structure of TRAPPII shows a similar architecture and suggests that the TRAPP complexes evolved from a single ur-TRAPP.
+
-
 
+
-
Cryo-EM structure of metazoan TRAPPIII, the multi-subunit complex that activates the GTPase Rab1.,Galindo A, Planelles-Herrero VJ, Degliesposti G, Munro S EMBO J. 2021 Jun 15;40(12):e107608. doi: 10.15252/embj.2020107608. Epub 2021 May , 21. PMID:34018214<ref>PMID:34018214</ref>
+
-
 
+
-
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+
-
</div>
+
-
<div class="pdbe-citations 7b6h" style="background-color:#fffaf0;"></div>
+
-
== References ==
+
-
<references/>
+
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Drome]]
+
[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Degliesposti, G]]
+
[[Category: Degliesposti G]]
-
[[Category: Galindo, A]]
+
[[Category: Galindo A]]
-
[[Category: Munro, S]]
+
[[Category: Munro S]]
-
[[Category: Planelles-Herrero, V J]]
+
[[Category: Planelles-Herrero VJ]]
-
[[Category: Exocytosis]]
+
-
[[Category: Gef]]
+
-
[[Category: Golgi]]
+
-
[[Category: Rab1]]
+
-
[[Category: Trapp]]
+

Current revision

Drosophila melanogaster TRAPP C11 subunits region 1 to 718

PDB ID 7b6h

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7b6h"
Personal tools