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2pyl

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Current revision (11:12, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2pyl' size='340' side='right'caption='[[2pyl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2pyl' size='340' side='right'caption='[[2pyl]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2pyl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bpph2 Bpph2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PYL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2pyl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_virus_phi29 Bacillus virus phi29]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PYL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=2DA:2,3-DIDEOXYADENOSINE-5-MONOPHOSPHATE'>2DA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2DA:2,3-DIDEOXYADENOSINE-5-MONOPHOSPHATE'>2DA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TTP:THYMIDINE-5-TRIPHOSPHATE'>TTP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2py5|2py5]], [[2pyj|2pyj]], [[2pzs|2pzs]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">2, gp2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10756 BPPH2])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyl OCA], [https://pdbe.org/2pyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pyl RCSB], [https://www.ebi.ac.uk/pdbsum/2pyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pyl OCA], [https://pdbe.org/2pyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pyl RCSB], [https://www.ebi.ac.uk/pdbsum/2pyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pyl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/DPOL_BPPH2 DPOL_BPPH2]] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.
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[https://www.uniprot.org/uniprot/DPOL_BPPH2 DPOL_BPPH2] This polymerase possesses two enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 2pyl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2pyl" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bpph2]]
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[[Category: Bacillus virus phi29]]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Berman, A J]]
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[[Category: Berman AJ]]
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[[Category: Blanco, L]]
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[[Category: Blanco L]]
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[[Category: Goodman, J L]]
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[[Category: Goodman JL]]
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[[Category: Kamtekar, S]]
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[[Category: Kamtekar S]]
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[[Category: Lazaro, J M]]
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[[Category: Lazaro JM]]
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[[Category: Salas, M]]
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[[Category: Salas M]]
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[[Category: Steitz, T A]]
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[[Category: Steitz TA]]
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[[Category: Vega, M de]]
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[[Category: De Vega M]]
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[[Category: Protein-dna complex]]
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[[Category: Replication]]
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[[Category: Transferase-dna complex]]
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Current revision

Phi29 DNA polymerase complexed with primer-template DNA and incoming nucleotide substrates (ternary complex)

PDB ID 2pyl

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OCA

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