|
|
| Line 3: |
Line 3: |
| | <StructureSection load='6xau' size='340' side='right'caption='[[6xau]], [[Resolution|resolution]] 1.89Å' scene=''> | | <StructureSection load='6xau' size='340' side='right'caption='[[6xau]], [[Resolution|resolution]] 1.89Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[6xau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAU FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xau]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XAU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XAU FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mecom, Evi1, Mds1, Prdm3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89Å</td></tr> |
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xau OCA], [https://pdbe.org/6xau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xau RCSB], [https://www.ebi.ac.uk/pdbsum/6xau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xau ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xau FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xau OCA], [https://pdbe.org/6xau PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xau RCSB], [https://www.ebi.ac.uk/pdbsum/6xau PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xau ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[https://www.uniprot.org/uniprot/MECOM_MOUSE MECOM_MOUSE]] Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.<ref>PMID:15889140</ref> <ref>PMID:18619962</ref> <ref>PMID:19767769</ref> Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.<ref>PMID:22939622</ref>
| + | [https://www.uniprot.org/uniprot/MECOM_MOUSE MECOM_MOUSE] Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.<ref>PMID:15889140</ref> <ref>PMID:18619962</ref> <ref>PMID:19767769</ref> Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.<ref>PMID:22939622</ref> |
| | + | |
| | + | ==See Also== |
| | + | *[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| Line 14: |
Line 17: |
| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Briknarova, K]] | + | [[Category: Briknarova K]] |
| - | [[Category: Loa, S]] | + | [[Category: Loa S]] |
| - | [[Category: Mou, T C]] | + | [[Category: Mou TC]] |
| - | [[Category: Sprang, S R]] | + | [[Category: Sprang SR]] |
| - | [[Category: Prdm3]]
| + | |
| - | [[Category: Transcription]]
| + | |
| Structural highlights
Function
MECOM_MOUSE Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.[1] [2] [3] Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation.[4]
See Also
References
- ↑ Yuasa H, Oike Y, Iwama A, Nishikata I, Sugiyama D, Perkins A, Mucenski ML, Suda T, Morishita K. Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J. 2005 Jun 1;24(11):1976-87. doi: 10.1038/sj.emboj.7600679. Epub 2005 May, 12. PMID:15889140 doi:http://dx.doi.org/10.1038/sj.emboj.7600679
- ↑ Spensberger D, Delwel R. A novel interaction between the proto-oncogene Evi1 and histone methyltransferases, SUV39H1 and G9a. FEBS Lett. 2008 Aug 6;582(18):2761-7. doi: 10.1016/j.febslet.2008.06.056. Epub, 2008 Jul 11. PMID:18619962 doi:http://dx.doi.org/10.1016/j.febslet.2008.06.056
- ↑ Shimabe M, Goyama S, Watanabe-Okochi N, Yoshimi A, Ichikawa M, Imai Y, Kurokawa M. Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells. Oncogene. 2009 Dec 10;28(49):4364-74. doi: 10.1038/onc.2009.288. PMID:19767769 doi:http://dx.doi.org/10.1038/onc.2009.288
- ↑ Pinheiro I, Margueron R, Shukeir N, Eisold M, Fritzsch C, Richter FM, Mittler G, Genoud C, Goyama S, Kurokawa M, Son J, Reinberg D, Lachner M, Jenuwein T. Prdm3 and Prdm16 are H3K9me1 methyltransferases required for mammalian heterochromatin integrity. Cell. 2012 Aug 31;150(5):948-60. doi: 10.1016/j.cell.2012.06.048. PMID:22939622 doi:http://dx.doi.org/10.1016/j.cell.2012.06.048
|
