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2q3e

From Proteopedia

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Current revision (11:17, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2q3e' size='340' side='right'caption='[[2q3e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2q3e' size='340' side='right'caption='[[2q3e]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2q3e]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2q3e]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3E FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UGDH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/UDP-glucose_6-dehydrogenase UDP-glucose 6-dehydrogenase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.22 1.1.1.22] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3e OCA], [https://pdbe.org/2q3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3e RCSB], [https://www.ebi.ac.uk/pdbsum/2q3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3e ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3e OCA], [https://pdbe.org/2q3e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3e RCSB], [https://www.ebi.ac.uk/pdbsum/2q3e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/UGDH_HUMAN UGDH_HUMAN]] Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
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[https://www.uniprot.org/uniprot/UGDH_HUMAN UGDH_HUMAN] Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: UDP-glucose 6-dehydrogenase]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C]]
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[[Category: Berridge G]]
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[[Category: Berridge, G]]
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[[Category: Bhatia C]]
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[[Category: Bhatia, C]]
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[[Category: Bunkoczi G]]
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[[Category: Bunkoczi, G]]
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[[Category: Edwards A]]
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[[Category: Delft, F von]]
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[[Category: Guo K]]
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[[Category: Edwards, A]]
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[[Category: Kavanagh KL]]
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[[Category: Guo, K]]
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[[Category: Oppermann U]]
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[[Category: Kavanagh, K L]]
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[[Category: Pilka E]]
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[[Category: Oppermann, U]]
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[[Category: Savitsky P]]
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[[Category: Pilka, E]]
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[[Category: Smee C]]
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[[Category: Structural genomic]]
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[[Category: Sundstrom M]]
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[[Category: Savitsky, P]]
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[[Category: Wiegelt J]]
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[[Category: Smee, C]]
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[[Category: Von Delft F]]
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[[Category: Sundstrom, M]]
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[[Category: Wiegelt, J]]
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[[Category: Hexamer]]
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[[Category: Oxidoreductase]]
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[[Category: Sgc]]
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[[Category: Udp-glucose 6-dehydrogenase]]
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Current revision

Structure of human UDP-glucose dehydrogenase complexed with NADH and UDP-glucose

PDB ID 2q3e

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