Ester protein crosslinks
From Proteopedia
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* [[4ni6]] REPEAT DOMAIN 1 OF CLOSTRIDIUM PERFRINGENS CPE0147 | * [[4ni6]] REPEAT DOMAIN 1 OF CLOSTRIDIUM PERFRINGENS CPE0147 | ||
* [[4mkm]] REPEAT DOMAINS 1 & 2 OF CLOSTRIDIUM PERFRINGENS CPE0147 | * [[4mkm]] REPEAT DOMAINS 1 & 2 OF CLOSTRIDIUM PERFRINGENS CPE0147 | ||
| + | |||
| + | ==Other Protein Crosslinks== | ||
| + | In addition to the Ester crosslinks discussed above, other covalent cross-links between polypeptide chains include: | ||
| + | *[[Disulfide bond]]s | ||
| + | *[[Isopeptide bond]]s | ||
| + | *[[Thioester protein crosslinks]] | ||
| + | *[[Lysine-cysteine NOS bonds]] | ||
==References== | ==References== | ||
<references /> | <references /> | ||
Revision as of 23:30, 30 June 2021
Ester bonds between threonine and glutamine sidechains can form covalent cross-links between polypeptide chains[1]. First observed in repetitive domains of a putative surface-anchored adhesin of Clostridium perfringens (Gram positive)[1], analysis of sequences suggested "that these intramolecular ester bonds are a widespread and common feature of cell surface adhesion proteins in Gram-positive bacteria"[1].
Examples
- 4ni6 REPEAT DOMAIN 1 OF CLOSTRIDIUM PERFRINGENS CPE0147
- 4mkm REPEAT DOMAINS 1 & 2 OF CLOSTRIDIUM PERFRINGENS CPE0147
Other Protein Crosslinks
In addition to the Ester crosslinks discussed above, other covalent cross-links between polypeptide chains include:
References
- ↑ 1.0 1.1 1.2 Kwon H, Squire CJ, Young PG, Baker EN. Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin. Proc Natl Acad Sci U S A. 2013 Dec 16. PMID:24344302 doi:http://dx.doi.org/10.1073/pnas.1316855111
