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6l2a

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Current revision (10:50, 22 November 2023) (edit) (undo)
 
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<StructureSection load='6l2a' size='340' side='right'caption='[[6l2a]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6l2a' size='340' side='right'caption='[[6l2a]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6l2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L2A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6l2a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6L2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6L2A FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mazF9 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9004467&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l2a OCA], [https://pdbe.org/6l2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l2a RCSB], [https://www.ebi.ac.uk/pdbsum/6l2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l2a ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6l2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6l2a OCA], [https://pdbe.org/6l2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6l2a RCSB], [https://www.ebi.ac.uk/pdbsum/6l2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6l2a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/A0A0E7Y7J2_MYCTX A0A0E7Y7J2_MYCTX]] Toxic component of a type II toxin-antitoxin (TA) system.[PIRNR:PIRNR033490]
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[https://www.uniprot.org/uniprot/MAZF9_MYCTU MAZF9_MYCTU] Toxic component of a type II toxin-antitoxin (TA) module. Upon expression in E.coli and M.smegmatis inhibits cell growth and colony formation. Its toxic effect is neutralized by coexpression with cognate antitoxin MazE9. Acts as an mRNA interferase, specifically cleaving between U and C in UAC sequences. May cleave its cognate antitoxin's gene (PubMed:25608501). In E.coli expression with non-cognate antitoxins VapB27 and VapB40 partially neutralizes the toxin.<ref>PMID:16611633</ref> <ref>PMID:19016878</ref> <ref>PMID:20011113</ref> <ref>PMID:20876537</ref> <ref>PMID:25608501</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Chen, R]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Xie, W]]
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[[Category: Chen R]]
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[[Category: Zhou, J]]
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[[Category: Xie W]]
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[[Category: Protein engineering]]
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[[Category: Zhou J]]
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[[Category: Rna endonlease]]
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[[Category: Toxin]]
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Current revision

A mutant form of M. tb toxin MazEF-mt1

PDB ID 6l2a

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OCA

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