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7lip

From Proteopedia

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Current revision (15:49, 18 October 2023) (edit) (undo)
 
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<StructureSection load='7lip' size='340' side='right'caption='[[7lip]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
<StructureSection load='7lip' size='340' side='right'caption='[[7lip]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7lip]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LIP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7lip]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LIP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.48&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPOP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lip OCA], [https://pdbe.org/7lip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lip RCSB], [https://www.ebi.ac.uk/pdbsum/7lip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lip ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lip OCA], [https://pdbe.org/7lip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lip RCSB], [https://www.ebi.ac.uk/pdbsum/7lip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lip ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN]] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref>
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[https://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7lip" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7lip" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Speckle-type POZ protein 3D structures|Speckle-type POZ protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Botuyan, M V]]
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[[Category: Botuyan MV]]
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[[Category: Cui, G]]
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[[Category: Cui G]]
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[[Category: Mer, G]]
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[[Category: Mer G]]
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[[Category: Dna damage response]]
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[[Category: Homologous recombination]]
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[[Category: Protein binding]]
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[[Category: Spop]]
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[[Category: Ubiquitin ligase]]
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Current revision

X-ray structure of SPOP MATH domain (D140G)

PDB ID 7lip

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