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| | <StructureSection load='2r3z' size='340' side='right'caption='[[2r3z]], [[Resolution|resolution]] 2.50Å' scene=''> | | <StructureSection load='2r3z' size='340' side='right'caption='[[2r3z]], [[Resolution|resolution]] 2.50Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R3Z FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2r3z]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R3Z FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1o7y|1o7y]], [[1o7z|1o7z]], [[1o80|1o80]]</div></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Cxcl10, Crg2, Ifi10, Inp10, Scyb10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
| + | |
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [https://pdbe.org/2r3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [https://www.ebi.ac.uk/pdbsum/2r3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r3z ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r3z OCA], [https://pdbe.org/2r3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r3z RCSB], [https://www.ebi.ac.uk/pdbsum/2r3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r3z ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[https://www.uniprot.org/uniprot/CXL10_MOUSE CXL10_MOUSE]] In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.
| + | [https://www.uniprot.org/uniprot/CXL10_MOUSE CXL10_MOUSE] In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development. |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Acharya, K R]] | + | [[Category: Acharya KR]] |
| - | [[Category: Jabeen, T]] | + | [[Category: Jabeen T]] |
| - | [[Category: Jamaluddin, H]] | + | [[Category: Jamaluddin H]] |
| - | [[Category: Leonard, P]] | + | [[Category: Leonard P]] |
| - | [[Category: Attractant]]
| + | |
| - | [[Category: Chemokine]]
| + | |
| - | [[Category: Chemotaxis]]
| + | |
| - | [[Category: Inflammatory response]]
| + | |
| - | [[Category: Ip-10/cxcl10]]
| + | |
| Structural highlights
Function
CXL10_MOUSE In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Interferon-gamma-inducible protein (IP-10) belongs to the CXC class of chemokines and plays a significant role in the pathophysiology of various immune and inflammatory responses. It is also a potent angiostatic factor with antifibrotic properties. The biological activities of IP-10 are exerted by interactions with the G-protein-coupled receptor CXCR3 expressed on Th1 lymphocytes. IP-10 thus forms an attractive target for structure-based rational drug design of anti-inflammatory molecules. The crystal structure of mouse IP-10 has been determined and reveals a novel tetrameric association. In the tetramer, two conventional CXC chemokine dimers are associated through their N-terminal regions to form a 12-stranded elongated beta-sheet of approximately 90 A in length. This association differs significantly from the previously studied tetramers of human IP-10, platelet factor 4 and neutrophil-activating peptide-2. In addition, heparin- and receptor-binding residues were mapped on the surface of IP-10 tetramer. Two heparin-binding sites were observed on the surface and were present at the interface of each of the two beta-sheet dimers. The structure supports the formation of higher order oligomers of IP-10, as observed in recent in vivo studies with mouse IP-10, which will have functional relevance.
Structure of mouse IP-10, a chemokine.,Jabeen T, Leonard P, Jamaluddin H, Acharya KR Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):611-9. Epub 2008, May 14. PMID:18560148[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Jabeen T, Leonard P, Jamaluddin H, Acharya KR. Structure of mouse IP-10, a chemokine. Acta Crystallogr D Biol Crystallogr. 2008 Jun;64(Pt 6):611-9. Epub 2008, May 14. PMID:18560148 doi:10.1107/S0907444908007026
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