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2r58

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Current revision (11:47, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2r58' size='340' side='right'caption='[[2r58]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2r58' size='340' side='right'caption='[[2r58]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2r58]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R58 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2r58]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R58 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2r57|2r57]], [[2r5a|2r5a]], [[2r5m|2r5m]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Scm ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r58 OCA], [https://pdbe.org/2r58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r58 RCSB], [https://www.ebi.ac.uk/pdbsum/2r58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r58 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r58 OCA], [https://pdbe.org/2r58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r58 RCSB], [https://www.ebi.ac.uk/pdbsum/2r58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r58 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SCM_DROME SCM_DROME]] Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.<ref>PMID:15280237</ref> [UniProtKB:Q9W3C1]
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[https://www.uniprot.org/uniprot/SCM_DROME SCM_DROME] Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility.<ref>PMID:15280237</ref> [UniProtKB:Q9W3C1]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Polycomb|Polycomb]]
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*[[Polycomb complex proteins 3D structures|Polycomb complex proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drome]]
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[[Category: Drosophila melanogaster]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Grimm, C]]
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[[Category: Grimm C]]
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[[Category: Mueller, C W]]
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[[Category: Mueller CW]]
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[[Category: Steuerwald, U]]
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[[Category: Steuerwald U]]
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[[Category: Chromatin regulator]]
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[[Category: Developmental protein]]
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[[Category: Di-methyl lysine]]
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[[Category: Mbt repeat]]
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[[Category: Metal-binding]]
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[[Category: Nucleus]]
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[[Category: Polycomb]]
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[[Category: Repressor]]
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[[Category: Sex comb on midleg]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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Current revision

Crystal Structure of the two MBT repeats from Sex-Comb on Midleg (SCM) in Complex with Di-Methyl Lysine

PDB ID 2r58

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