2rah

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Current revision (11:52, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2rah' size='340' side='right'caption='[[2rah]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2rah' size='340' side='right'caption='[[2rah]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2rah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RAH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2rah]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RAH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RAH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=11P:[(7R)-6,7-DIHYDRO-5H-CYCLOPENTA[C]PYRIDIN-7-YL(HYDROXY)METHYLENE]BIS(PHOSPHONIC+ACID)'>11P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1zw5|1zw5]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=11P:[(7R)-6,7-DIHYDRO-5H-CYCLOPENTA[C]PYRIDIN-7-YL(HYDROXY)METHYLENE]BIS(PHOSPHONIC+ACID)'>11P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rah OCA], [https://pdbe.org/2rah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rah RCSB], [https://www.ebi.ac.uk/pdbsum/2rah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rah ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rah FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rah OCA], [https://pdbe.org/2rah PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rah RCSB], [https://www.ebi.ac.uk/pdbsum/2rah PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rah ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Barnett, B L]]
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[[Category: Barnett BL]]
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[[Category: Ebetino, F H]]
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[[Category: Ebetino FH]]
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[[Category: Evdokimov, A G]]
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[[Category: Evdokimov AG]]
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[[Category: Pokross, M]]
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[[Category: Pokross M]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Cytoplasm]]
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[[Category: Host-virus interaction]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Lipid synthesis]]
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[[Category: Mainly alpha]]
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[[Category: Orthogonal bundle]]
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[[Category: Osteoporosis]]
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[[Category: Steroid biosynthesis]]
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[[Category: Sterol biosynthesis]]
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[[Category: Transferase]]
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Current revision

Human FDPS synthase in complex with novel inhibitor

PDB ID 2rah

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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