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2rjr

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Current revision (11:58, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2rjr' size='340' side='right'caption='[[2rjr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2rjr' size='340' side='right'caption='[[2rjr]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"actinomyces_globisporus"_krasil'nikov_1941 "actinomyces globisporus" krasil'nikov 1941]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2rjr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_globisporus Streptomyces globisporus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RJR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RJR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=295:(2S,3S)-3-(4-FLUOROPHENYL)-2,3-DIHYDROXYPROPANOIC+ACID'>295</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=295:(2S,3S)-3-(4-FLUOROPHENYL)-2,3-DIHYDROXYPROPANOIC+ACID'>295</scene>, <scene name='pdbligand=MDO:{2-[(1S)-1-AMINOETHYL]-4-METHYLIDENE-5-OXO-4,5-DIHYDRO-1H-IMIDAZOL-1-YL}ACETIC+ACID'>MDO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ohy|2ohy]], [[2qve|2qve]], [[2rjs|2rjs]]</div></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SgcC4 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1908 "Actinomyces globisporus" Krasil'nikov 1941])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Tyrosine_2,3-aminomutase Tyrosine 2,3-aminomutase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.3.6 5.4.3.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [https://pdbe.org/2rjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [https://www.ebi.ac.uk/pdbsum/2rjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rjr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rjr OCA], [https://pdbe.org/2rjr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rjr RCSB], [https://www.ebi.ac.uk/pdbsum/2rjr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rjr ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TAM_STRGL TAM_STRGL] Involved in the biosynthesis of the enediyne antitumor antibiotic C-1027. Catalyzes the MIO-dependent deamination of L-tyrosine generating the corresponding alpha,beta-unsaturated acid, (S)-beta-tyrosine.<ref>PMID:12183628</ref> <ref>PMID:17516659</ref> <ref>PMID:20577998</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Actinomyces globisporus krasil'nikov 1941]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tyrosine 2,3-aminomutase]]
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[[Category: Streptomyces globisporus]]
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[[Category: Bruner, S D]]
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[[Category: Bruner SD]]
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[[Category: Christianson, C V]]
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[[Category: Christianson CV]]
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[[Category: Montavon, T J]]
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[[Category: Montavon TJ]]
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[[Category: 4-methylidene imidizole]]
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[[Category: Aminomutase]]
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[[Category: C-1027]]
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[[Category: Isomerase]]
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[[Category: Mio]]
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Current revision

Substrate mimic bound to SgTAM

PDB ID 2rjr

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OCA

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