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Thioether protein crosslinks

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Thioether bonds between '''cysteine and tyrosine''' have been well studied in cysteine dioxygenases<ref>PMID:25390690</ref>. Thioether bonds between '''cysteine and the vinyl groups of hemes''' are common. Diverse other '''ligands''' are bonded to protein via cysteine thioether linkages.
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Thioether bonds between the sidechains of '''cysteine and tyrosine''' have been well studied in cysteine dioxygenases<ref>PMID:25390690</ref>. Thioether bonds between '''cysteine and the vinyl groups of hemes''' are common. Diverse other '''ligands''' are bonded to protein via cysteine thioether linkages. (Note that the sidechain of methionine contains a thioether.)
An accurate estimate of the frequency of thioethers in the [[PDB]] may not be available. A search for "thioether" in Proteopedia yields >200 hits in abstracts of pages titled with 4-character [[PDB codes]].
An accurate estimate of the frequency of thioethers in the [[PDB]] may not be available. A search for "thioether" in Proteopedia yields >200 hits in abstracts of pages titled with 4-character [[PDB codes]].

Revision as of 20:12, 4 July 2021

Thioether bonds between the sidechains of cysteine and tyrosine have been well studied in cysteine dioxygenases[1]. Thioether bonds between cysteine and the vinyl groups of hemes are common. Diverse other ligands are bonded to protein via cysteine thioether linkages. (Note that the sidechain of methionine contains a thioether.)

An accurate estimate of the frequency of thioethers in the PDB may not be available. A search for "thioether" in Proteopedia yields >200 hits in abstracts of pages titled with 4-character PDB codes.

Contents

Examples

Cys-Tyr

  • 6e87 (2019): Cysteine dioxygenase.

Cys-Ligand

References

  1. ↑ Davies CG, Fellner M, Tchesnokov EP, Wilbanks SM, Jameson GN. The Cys-Tyr Crosslink of Cysteine Dioxygenase changes the Optimum pH of Reaction without Structural Change. Biochemistry. 2014 Nov 12. PMID:25390690 doi:http://dx.doi.org/10.1021/bi501277a

Proteopedia Page Contributors and Editors (what is this?)

Eric Martz

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