1erh

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[[Image:1erh.jpg|left|200px]]
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{{Seed}}
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[[Image:1erh.png|left|200px]]
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{{STRUCTURE_1erh| PDB=1erh | SCENE= }}
{{STRUCTURE_1erh| PDB=1erh | SCENE= }}
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'''THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE EXTRACELLULAR REGION OF THE COMPLEMENT REGULATORY PROTEIN, CD59, A NEW CELL SURFACE PROTEIN DOMAIN RELATED TO NEUROTOXINS'''
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===THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE EXTRACELLULAR REGION OF THE COMPLEMENT REGULATORY PROTEIN, CD59, A NEW CELL SURFACE PROTEIN DOMAIN RELATED TO NEUROTOXINS===
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==Overview==
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The cell surface antigen CD59 is an inhibitor of complement-mediated lysis and a member of the Ly6 superfamily (Ly6SF) of cysteine-rich cell-surface molecules whose sequences are related to those of snake venom neurotoxins. The three-dimensional solution structure of a recombinant form of the extracellular region of the molecule (residues 1-70 of the mature protein; sCD59) has been solved by 2D NMR methods. sCD59 is a relatively flat, disk-shaped molecule consisting of a two-standed beta-sheet finger loosely packed against a protein core formed by a three-stranded beta-sheet and a short helix. Structure calculations allowed an unambiguous assignment of the disulfide-bonded cysteine pairs as 3-26, 6-13, 19-39, 45-63, and 64-69. The topology of sCD59 is similar to that of the snake venom neurotoxins and consistent with an evolutionary relationship existing between the Ly6SF and the neurotoxins.
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The line below this paragraph, {{ABSTRACT_PUBMED_7512825}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 7512825 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7512825}}
==About this Structure==
==About this Structure==
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1ERH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ERH OCA].
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1ERH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ERH OCA].
==Reference==
==Reference==
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[[Category: Willis, A C.]]
[[Category: Willis, A C.]]
[[Category: Complement factor]]
[[Category: Complement factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:26:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:45:34 2008''

Revision as of 22:45, 30 June 2008

Image:1erh.png

Template:STRUCTURE 1erh

THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE EXTRACELLULAR REGION OF THE COMPLEMENT REGULATORY PROTEIN, CD59, A NEW CELL SURFACE PROTEIN DOMAIN RELATED TO NEUROTOXINS

Template:ABSTRACT PUBMED 7512825

About this Structure

1ERH is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Three-dimensional solution structure of the extracellular region of the complement regulatory protein CD59, a new cell-surface protein domain related to snake venom neurotoxins., Kieffer B, Driscoll PC, Campbell ID, Willis AC, van der Merwe PA, Davis SJ, Biochemistry. 1994 Apr 19;33(15):4471-82. PMID:7512825

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