1erj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1erj.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1erj.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1erj| PDB=1erj | SCENE= }}
{{STRUCTURE_1erj| PDB=1erj | SCENE= }}
-
'''CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1'''
+
===CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1===
-
==Overview==
+
<!--
-
The Tup1-Ssn6 corepressor complex regulates the expression of several sets of genes, including genes that specify mating type in the yeast Saccharomyces cerevisiae. Repression of mating-type genes occurs when Tup1-Ssn6 is brought to the DNA by the Matalpha2 DNA-binding protein and assembled upstream of a- and haploid-specific genes. We have determined the 2.3 A X-ray crystal structure of the C-terminal domain of Tup1 (accesion No. 1ERJ), a 43 kDa fragment that contains seven copies of the WD40 sequence motif and binds to the Matalpha2 protein. Moreover, this portion of the protein can partially substitute for full-length Tup1 in bringing about transcriptional repression. The structure reveals a seven-bladed beta propeller with an N-terminal subdomain that is anchored to the side of the propeller and extends the beta sheet of one of the blades. Point mutations in Tup1 that specifically affect the Tup1-Matalpha2 interaction cluster on one surface of the propeller. We identified regions of Tup1 that are conserved among the fungal Tup1 homologs and may be important in protein-protein interactions with additional components of the Tup1-mediated repression pathways.
+
The line below this paragraph, {{ABSTRACT_PUBMED_10856245}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 10856245 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_10856245}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Wolberger, C.]]
[[Category: Wolberger, C.]]
[[Category: Beta-propeller]]
[[Category: Beta-propeller]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:26:21 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:45:58 2008''

Revision as of 22:46, 30 June 2008

Image:1erj.png

Template:STRUCTURE 1erj

CRYSTAL STRUCTURE OF THE C-TERMINAL WD40 DOMAIN OF TUP1

Template:ABSTRACT PUBMED 10856245

About this Structure

1ERJ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of the C-terminal domain of Tup1, a corepressor of transcription in yeast., Sprague ER, Redd MJ, Johnson AD, Wolberger C, EMBO J. 2000 Jun 15;19(12):3016-27. PMID:10856245

Page seeded by OCA on Tue Jul 1 01:45:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1erj"
Personal tools