7r8r
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Physachenolide C with Bromodomain (BRD3-BD1)== | |
| - | + | <StructureSection load='7r8r' size='340' side='right'caption='[[7r8r]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7r8r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R8R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R8R FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8L6:Physachenolide+C'>8L6</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r8r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r8r OCA], [https://pdbe.org/7r8r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r8r RCSB], [https://www.ebi.ac.uk/pdbsum/7r8r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r8r ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chapman E]] | ||
| + | [[Category: Fromme R]] | ||
| + | [[Category: Gunatilaka AAL]] | ||
| + | [[Category: Sivinski J]] | ||
| + | [[Category: Zerio C]] | ||
Revision as of 07:37, 21 September 2022
Physachenolide C with Bromodomain (BRD3-BD1)
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