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7a3k
From Proteopedia
(Difference between revisions)
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==Crystal structure of DPP8 in complex with a b-lactam based inhibitor, A296.1== | ==Crystal structure of DPP8 in complex with a b-lactam based inhibitor, A296.1== | ||
| - | <StructureSection load='7a3k' size='340' side='right'caption='[[7a3k]]' scene=''> | + | <StructureSection load='7a3k' size='340' side='right'caption='[[7a3k]], [[Resolution|resolution]] 2.65Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A3K FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7a3k]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A3K FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a3k OCA], [https://pdbe.org/7a3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a3k RCSB], [https://www.ebi.ac.uk/pdbsum/7a3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a3k ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=QX8:1-[3-[[4-[(4-bromophenyl)methyl]piperazin-1-yl]methyl]phenyl]azetidin-2-one'>QX8</scene>, <scene name='pdbligand=TMO:TRIMETHYLAMINE+OXIDE'>TMO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a3k OCA], [https://pdbe.org/7a3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a3k RCSB], [https://www.ebi.ac.uk/pdbsum/7a3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a3k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DPP8_HUMAN DPP8_HUMAN] Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. May play a role in T-cell activation and immune function.<ref>PMID:11012666</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Dipeptidyl peptidase 3D structures|Dipeptidyl peptidase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Huber R]] | [[Category: Huber R]] | ||
[[Category: Ross BH]] | [[Category: Ross BH]] | ||
Current revision
Crystal structure of DPP8 in complex with a b-lactam based inhibitor, A296.1
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