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1esg

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[[Image:1esg.gif|left|200px]]
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{{Seed}}
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[[Image:1esg.png|left|200px]]
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{{STRUCTURE_1esg| PDB=1esg | SCENE= }}
{{STRUCTURE_1esg| PDB=1esg | SCENE= }}
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'''RESTRICTION ENDONUCLEASE BAMHI BOUND TO A NON-SPECIFIC DNA.'''
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===RESTRICTION ENDONUCLEASE BAMHI BOUND TO A NON-SPECIFIC DNA.===
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==Overview==
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The central problem faced by DNA binding proteins is how to select the correct DNA sequence from the sea of nonspecific sequences in a cell. The problem is particularly acute for bacterial restriction enzymes because cleavage at an incorrect DNA site could be lethal. To understand the basis of this selectivity, we report here the crystal structure of endonuclease BamHI bound to noncognate DNA. We show that, despite only a single base pair change in the recognition sequence, the enzyme adopts an open configuration that is on the pathway between free and specifically bound forms of the enzyme. Surprisingly, the DNA drops out of the binding cleft with a total loss of base-specific and backbone contacts. Taken together, the structure provides a remarkable snapshot of an enzyme poised for linear diffusion (rather than cleavage) along the DNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_10882125}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 10882125 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10882125}}
==About this Structure==
==About this Structure==
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[[Category: Viadiu, H.]]
[[Category: Viadiu, H.]]
[[Category: Non-specific dna-protein complex.]]
[[Category: Non-specific dna-protein complex.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:28:03 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:48:47 2008''

Revision as of 22:48, 30 June 2008

Image:1esg.png

Template:STRUCTURE 1esg

RESTRICTION ENDONUCLEASE BAMHI BOUND TO A NON-SPECIFIC DNA.

Template:ABSTRACT PUBMED 10882125

About this Structure

1ESG is a Single protein structure of sequence from Bacillus amyloliquefaciens. Full crystallographic information is available from OCA.

Reference

Structure of BamHI bound to nonspecific DNA: a model for DNA sliding., Viadiu H, Aggarwal AK, Mol Cell. 2000 May;5(5):889-95. PMID:10882125

Page seeded by OCA on Tue Jul 1 01:48:47 2008

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