This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7e14
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | ==== | + | ==Compound2_GLP-1R_OWL833_Gs complex structure== |
| - | <StructureSection load='7e14' size='340' side='right'caption='[[7e14]]' scene=''> | + | <StructureSection load='7e14' size='340' side='right'caption='[[7e14]], [[Resolution|resolution]] 2.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7e14]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E14 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E14 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e14 OCA], [https://pdbe.org/7e14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e14 RCSB], [https://www.ebi.ac.uk/pdbsum/7e14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e14 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=HNO:N-tert-butyl-6,7-bis(chloranyl)quinoxalin-2-amine'>HNO</scene>, <scene name='pdbligand=V6G:3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one'>V6G</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e14 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e14 OCA], [https://pdbe.org/7e14 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e14 RCSB], [https://www.ebi.ac.uk/pdbsum/7e14 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e14 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Glucagon-like peptide receptor 3D structures|Glucagon-like peptide receptor 3D structures]] | ||
| + | *[[Transducin 3D structures|Transducin 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Chen LN]] | ||
| + | [[Category: Cong ZT]] | ||
| + | [[Category: Ma HL]] | ||
| + | [[Category: Wang MW]] | ||
| + | [[Category: Xu HE]] | ||
| + | [[Category: Yang DH]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
Compound2_GLP-1R_OWL833_Gs complex structure
| |||||||||||
Categories: Bos taurus | Homo sapiens | Large Structures | Rattus norvegicus | Synthetic construct | Chen LN | Cong ZT | Ma HL | Wang MW | Xu HE | Yang DH | Zhang Y
