2vi5
From Proteopedia
(Difference between revisions)
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<StructureSection load='2vi5' size='340' side='right'caption='[[2vi5]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2vi5' size='340' side='right'caption='[[2vi5]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2vi5]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2vi5]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VI5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=Y19:1-DEOXY-1-{[(5S)-2,6-DIOXO-5-(PROPANOYLAMINO)-1,2,5,6-TETRAHYDROPYRIMIDIN-4-YL]AMINO}-D-RIBITOL'>Y19</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=Y19:1-DEOXY-1-{[(5S)-2,6-DIOXO-5-(PROPANOYLAMINO)-1,2,5,6-TETRAHYDROPYRIMIDIN-4-YL]AMINO}-D-RIBITOL'>Y19</scene></td></tr> | |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vi5 OCA], [https://pdbe.org/2vi5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vi5 RCSB], [https://www.ebi.ac.uk/pdbsum/2vi5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vi5 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vi5 OCA], [https://pdbe.org/2vi5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vi5 RCSB], [https://www.ebi.ac.uk/pdbsum/2vi5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vi5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/RISB_MYCTU RISB_MYCTU] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:15723519</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Riboflavin synthase]] | ||
| - | [[Category: Bacher, A]] | ||
| - | [[Category: Cushman, M]] | ||
| - | [[Category: Fischer, M]] | ||
| - | [[Category: Illarionov, B]] | ||
| - | [[Category: Jin, G]] | ||
| - | [[Category: Ladenstein, R]] | ||
| - | [[Category: Morgunova, E]] | ||
| - | [[Category: Zhang, Y]] | ||
| - | [[Category: Lumazine synthase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: | + | [[Category: Bacher A]] |
| - | [[Category: | + | [[Category: Cushman M]] |
| + | [[Category: Fischer M]] | ||
| + | [[Category: Illarionov B]] | ||
| + | [[Category: Jin G]] | ||
| + | [[Category: Ladenstein R]] | ||
| + | [[Category: Morgunova E]] | ||
| + | [[Category: Zhang Y]] | ||
Current revision
LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO N-6-(ribitylamino)pyrimidine-2,4(1H,3H)-dione-5-yl-propionamide
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