2vnn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:00, 23 October 2024) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='2vnn' size='340' side='right'caption='[[2vnn]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
<StructureSection load='2vnn' size='340' side='right'caption='[[2vnn]], [[Resolution|resolution]] 1.87&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2vnn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VNN FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2vnn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VNN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VNN FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CM7:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-7-ETHYL-1-METHYL-3,4-DIHYDRO-1H-[1,2,5]THIADIAZEPINO[3,4,5-HI]INDOLE-9-CARBOXAMIDE+2,2-DIOXIDE'>CM7</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1m4h|1m4h]], [[1sgz|1sgz]], [[1w50|1w50]], [[1w51|1w51]], [[1xs7|1xs7]], [[1ym4|1ym4]], [[2viz|2viz]], [[2vj6|2vj6]], [[1fkn|1fkn]], [[1py1|1py1]], [[1tqf|1tqf]], [[1ujj|1ujj]], [[1ujk|1ujk]], [[1xn2|1xn2]], [[1xn3|1xn3]], [[1ym2|1ym2]], [[2b8l|2b8l]], [[2b8v|2b8v]], [[2va5|2va5]], [[2va6|2va6]], [[2va7|2va7]], [[2vie|2vie]], [[2vij|2vij]], [[2viy|2viy]], [[2vj7|2vj7]], [[2vj9|2vj9]], [[2vkm|2vkm]], [[2vnm|2vnm]]</div></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CM7:N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{[3-(TRIFLUOROMETHYL)BENZYL]AMINO}PROPYL]-7-ETHYL-1-METHYL-3,4-DIHYDRO-1H-[1,2,5]THIADIAZEPINO[3,4,5-HI]INDOLE-9-CARBOXAMIDE+2,2-DIOXIDE'>CM7</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnn OCA], [https://pdbe.org/2vnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vnn RCSB], [https://www.ebi.ac.uk/pdbsum/2vnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vnn ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vnn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vnn OCA], [https://pdbe.org/2vnn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vnn RCSB], [https://www.ebi.ac.uk/pdbsum/2vnn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vnn ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
+
[https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 16: Line 15:
<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vnn_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vn/2vnn_consurf.spt"</scriptWhenChecked>
-
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
Line 37: Line 36:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Memapsin 2]]
+
[[Category: Charrier N]]
-
[[Category: Charrier, N]]
+
[[Category: Clarke B]]
-
[[Category: Clarke, B]]
+
[[Category: Cutler L]]
-
[[Category: Cutler, L]]
+
[[Category: Demont E]]
-
[[Category: Demont, E]]
+
[[Category: Dingwall C]]
-
[[Category: Dingwall, C]]
+
[[Category: Dunsdon R]]
-
[[Category: Dunsdon, R]]
+
[[Category: East P]]
-
[[Category: East, P]]
+
[[Category: Hawkins J]]
-
[[Category: Hawkins, J]]
+
[[Category: Howes C]]
-
[[Category: Howes, C]]
+
[[Category: Hussain I]]
-
[[Category: Hussain, I]]
+
[[Category: Jeffrey P]]
-
[[Category: Jeffrey, P]]
+
[[Category: Maile G]]
-
[[Category: Maile, G]]
+
[[Category: Matico R]]
-
[[Category: Matico, R]]
+
[[Category: Mosley J]]
-
[[Category: Mosley, J]]
+
[[Category: Naylor A]]
-
[[Category: Naylor, A]]
+
[[Category: OBrien A]]
-
[[Category: OBrien, A]]
+
[[Category: Redshaw S]]
-
[[Category: Redshaw, S]]
+
[[Category: Rowland P]]
-
[[Category: Rowland, P]]
+
[[Category: Smith KJ]]
-
[[Category: Smith, K J]]
+
[[Category: Soleil V]]
-
[[Category: Soleil, V]]
+
[[Category: Sweitzer S]]
-
[[Category: Sweitzer, S]]
+
[[Category: Theobald P]]
-
[[Category: Theobald, P]]
+
[[Category: Vesey D]]
-
[[Category: Vesey, D]]
+
[[Category: Walter DS]]
-
[[Category: Walter, D S]]
+
[[Category: Wayne G]]
-
[[Category: Wayne, G]]
+
-
[[Category: Alternative splicing]]
+
-
[[Category: Asp-2]]
+
-
[[Category: Aspartyl protease]]
+
-
[[Category: Bace-1]]
+
-
[[Category: Beta-secretase]]
+
-
[[Category: Beta-site app cleaving enzyme]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Memapsin-2]]
+
-
[[Category: Membrane]]
+
-
[[Category: Protease]]
+
-
[[Category: Transmembrane]]
+
-
[[Category: Zymogen]]
+

Current revision

Human BACE-1 in complex with 7-ethyl-N-((1S,2R)-2-hydroxy-1-(phenylmethyl)-3-(((3-(trifluoromethyl)phenyl)methyl)amino)propyl)-1- methyl-3,4-dihydro-1H-(1,2,5)thiadiazepino(3,4,5-hi)indole-9- carboxamide 2,2-dioxide

PDB ID 2vnn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vnn"
Personal tools