2vt4

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<StructureSection load='2vt4' size='340' side='right'caption='[[2vt4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2vt4' size='340' side='right'caption='[[2vt4]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2vt4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Melga Melga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VT4 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2vt4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Meleagris_gallopavo Meleagris gallopavo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VT4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VT4 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P32:4-{[(2S)-3-(TERT-BUTYLAMINO)-2-HYDROXYPROPYL]OXY}-3H-INDOLE-2-CARBONITRILE'>P32</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1dep|1dep]], [[2rh1|2rh1]], [[2r4r|2r4r]], [[2r4s|2r4s]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=P32:4-{[(2S)-3-(TERT-BUTYLAMINO)-2-HYDROXYPROPYL]OXY}-3H-INDOLE-2-CARBONITRILE'>P32</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vt4 OCA], [https://pdbe.org/2vt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vt4 RCSB], [https://www.ebi.ac.uk/pdbsum/2vt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vt4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vt4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vt4 OCA], [https://pdbe.org/2vt4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vt4 RCSB], [https://www.ebi.ac.uk/pdbsum/2vt4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vt4 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ADRB1_MELGA ADRB1_MELGA] Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Melga]]
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[[Category: Meleagris gallopavo]]
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[[Category: Baker, J G]]
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[[Category: Baker JG]]
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[[Category: Edwards, P C]]
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[[Category: Edwards PC]]
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[[Category: Henderson, R]]
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[[Category: Henderson R]]
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[[Category: Leslie, A G.W]]
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[[Category: Leslie AGW]]
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[[Category: Moukhametzianov, R]]
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[[Category: Moukhametzianov R]]
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[[Category: Schertler, G F.X]]
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[[Category: Schertler GFX]]
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[[Category: Serrano-Vega, M J]]
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[[Category: Serrano-Vega MJ]]
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[[Category: Tate, C G]]
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[[Category: Tate CG]]
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[[Category: Warne, A]]
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[[Category: Warne A]]
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[[Category: 7tm receptor]]
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[[Category: Antagonist bound form]]
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[[Category: G protein coupled receptor]]
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[[Category: G-protein coupled receptor]]
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[[Category: Glycoprotein]]
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[[Category: Gpcr]]
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[[Category: Integral membrane protein]]
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[[Category: Lipoprotein]]
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[[Category: Membrane]]
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[[Category: Palmitate]]
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[[Category: Phosphoprotein]]
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[[Category: Receptor]]
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[[Category: Seven-helix receptor]]
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[[Category: Thermostabilising point mutation]]
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[[Category: Transducer]]
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[[Category: Transmembrane]]
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Revision as of 15:31, 13 December 2023

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL

PDB ID 2vt4

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OCA

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